http://www.cnr.it/ontology/cnr/individuo/prodotto/ID167767
Structure, function, and evolution of the tRNA endonucleases of Archaea: an example of subfunctionalization. (Articolo in rivista)
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- Label
- Structure, function, and evolution of the tRNA endonucleases of Archaea: an example of subfunctionalization. (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1073/pnas.0502350102 (literal)
- Alternative label
Tocchini-Valentini G.D.; Fruscoloni P.; Tocchini-Valentini G.P. (2005)
Structure, function, and evolution of the tRNA endonucleases of Archaea: an example of subfunctionalization.
in Proceedings of the National Academy of Sciences of the United States of America
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Tocchini-Valentini G.D.; Fruscoloni P.; Tocchini-Valentini G.P. (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.pnas.org/content/102/25/8933 (literal)
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- Rivista
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- Commented in: Hughes AL. Proc Natl Acad Sci U S A. 2005 102:8791-2 Impact Factor = 10.452 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
- Pubblicazione su rivista internazionale (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Fruscoloni, Tocchini-VAlentini GP: Istituto di Biologia Cellulare, CNR, Roma, Italy
Tocchini-VAlentini GD: IGM-CNR (literal)
- Titolo
- Structure, function, and evolution of the tRNA endonucleases of Archaea: an example of subfunctionalization. (literal)
- Abstract
- We have detected two paralogs of the tRNA endonuclease gene of Methanocaldococcus jannaschii in the genome of the crenarchaeote Sulfolobus solfataricus. This finding has led to the discovery of a previously unrecognized oligomeric form of the enzyme. The two genes code for two different subunits, both of which are required for cleavage of the pre-tRNA substrate. Thus, there are now three forms of tRNA endonuclease in the Archaea: a homotetramer in some Euryarchaea, a homodimer in other Euryarchaea, and a heterotetramer in the Crenarchaea and the Nanoarchaea. The last-named enzyme, arising most likely by gene duplication and subsequent \"subfunctionalization,\" requires the products of both genes to be active. (literal)
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