Structure, function, and evolution of the tRNA endonucleases of Archaea: an example of subfunctionalization. (Articolo in rivista)

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  • Structure, function, and evolution of the tRNA endonucleases of Archaea: an example of subfunctionalization. (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1073/pnas.0502350102 (literal)
Alternative label
  • Tocchini-Valentini G.D.; Fruscoloni P.; Tocchini-Valentini G.P. (2005)
    Structure, function, and evolution of the tRNA endonucleases of Archaea: an example of subfunctionalization.
    in Proceedings of the National Academy of Sciences of the United States of America
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Tocchini-Valentini G.D.; Fruscoloni P.; Tocchini-Valentini G.P. (literal)
Pagina inizio
  • 8933 (literal)
Pagina fine
  • 8938 (literal)
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  • http://www.pnas.org/content/102/25/8933 (literal)
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  • 102 (literal)
Rivista
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  • Commented in: Hughes AL. Proc Natl Acad Sci U S A. 2005 102:8791-2 Impact Factor = 10.452 (literal)
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  • Pubblicazione su rivista internazionale (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Fruscoloni, Tocchini-VAlentini GP: Istituto di Biologia Cellulare, CNR, Roma, Italy Tocchini-VAlentini GD: IGM-CNR (literal)
Titolo
  • Structure, function, and evolution of the tRNA endonucleases of Archaea: an example of subfunctionalization. (literal)
Abstract
  • We have detected two paralogs of the tRNA endonuclease gene of Methanocaldococcus jannaschii in the genome of the crenarchaeote Sulfolobus solfataricus. This finding has led to the discovery of a previously unrecognized oligomeric form of the enzyme. The two genes code for two different subunits, both of which are required for cleavage of the pre-tRNA substrate. Thus, there are now three forms of tRNA endonuclease in the Archaea: a homotetramer in some Euryarchaea, a homodimer in other Euryarchaea, and a heterotetramer in the Crenarchaea and the Nanoarchaea. The last-named enzyme, arising most likely by gene duplication and subsequent \"subfunctionalization,\" requires the products of both genes to be active. (literal)
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