Globular structure of human ovulatory cervical mucus (Articolo in rivista)

Type
Label
  • Globular structure of human ovulatory cervical mucus (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1096/fj.07-8189com (literal)
Alternative label
  • Roberto Brunelli1; Massimiliano Papi2; Giuseppe Arcovito2; Adriano Bompiani3; Massimo Castagnola4,3,5; Tiziana Parasassi6; Beatrice Sampaolese5; Federica Vincenzoni3; Marco De Spirito2 (2007)
    Globular structure of human ovulatory cervical mucus
    in The FASEB journal
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Roberto Brunelli1; Massimiliano Papi2; Giuseppe Arcovito2; Adriano Bompiani3; Massimo Castagnola4,3,5; Tiziana Parasassi6; Beatrice Sampaolese5; Federica Vincenzoni3; Marco De Spirito2 (literal)
Pagina inizio
  • 3872 (literal)
Pagina fine
  • 3876 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 21 (literal)
Rivista
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  • Epub ahead of print (literal)
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  • 14 (literal)
Note
  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Dipartimento di Scienze Ginecologiche, Perinatologia e Puericultura, Universit√† di Roma La Sapienza, Italy; 2 Istituto di Fisica; 3 Istituto Scientifico Internazionale \"Paolo VI,\" Rome, Italy; 4 Istituto di Biochimica e Biochimica clinica, Facolt√† di Medicina e Chirurgia, Universit√† Cattolica del Sacro Cuore, Rome, Italy; 5 Istituto per la Chimica del Riconscimento Molecolare; 6 Istituto di Neurobiologia e Medicina Molecolare, CNR, Rome, Italy. (literal)
Titolo
  • Globular structure of human ovulatory cervical mucus (literal)
Abstract
  • Human cervical mucus is a heterogeneous mixture of mucin glycoproteins whose relative concentration changes during the ovulatory phases, thereby producing different mucus aggregation structures that can periodically permit the transit of spermatozoa for fertilization. In preovulatory phase, mucus is arranged in compact fiber-like structures where sperm transit is hindered. Previously, through observations made of fixed and dehydrated samples, a permissive structure in the ovulatory phase was attributed to the larger diameters of pores in the mucus network. Instead, by means of atomic force microscopy, we can show, for the first time, that unfixed ovulatory mucus is composed by floating globules of mucin aggregates. This finding sheds new light on the mechanism that governs spermatozoa transit toward the uterine cavity. In addition, we demonstrate that the switch from globular ovulatory to fibrous preovulatory mucus largely depends on a pH-driven mechanism. Analysis of mucin 5B primary sequence, the main mucin in ovulatory mucus, highlights pH-sensitive domains that are associated to flexible regions prone to drive aggregation. We suggest an involvement of these domains in the fiber (literal)
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