High plasma levels of the soluble receptor for advanced glycation endproducts in patients with symptomatic carotid atherosclerosis (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• High plasma levels of the soluble receptor for advanced glycation endproducts in patients with symptomatic carotid atherosclerosis (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1111/j.1365-2362.2009.02212.x (literal)

Alternative label

• Basta G.; Castagnini M.; Del Turco S.; Epistolato M. C.; Righini P.; Sangiorgi G. M.; De Caterina R.; Tanganelli P. (2009)
  High plasma levels of the soluble receptor for advanced glycation endproducts in patients with symptomatic carotid atherosclerosis
  in European journal of clinical investigation (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Basta G.; Castagnini M.; Del Turco S.; Epistolato M. C.; Righini P.; Sangiorgi G. M.; De Caterina R.; Tanganelli P. (literal)

Pagina inizio

• 1065 (literal)

Pagina fine

• 1072 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 39 (literal)

Rivista

• European journal of clinical investigation (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• In: European Journal of Clinical Investigation, vol. 39 (12) pp. 1065 - 1072. Wiley InterScience, 2009. (literal)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR-IFC, Pisa, University of Siena, Humanitas Clinical Institute, IRCCS, Rozzano, Milano, EMO Columbus Heart Centre, Milano, G. D'Annunzio, Chieti (literal)

Titolo

• High plasma levels of the soluble receptor for advanced glycation endproducts in patients with symptomatic carotid atherosclerosis (literal)

Abstract

• Background Advanced glycation endproducts (AGEs), particularly carboxymethyl(lysine)-adducts (CML), exert part of their cellular effects by binding to a receptor, named receptor for AGEs (RAGE). The soluble form of this receptor (sRAGE) has been shown to have an athero-protective role. We hypothesized the existence of a relationship between the AGE-RAGE axis and the occurrence of symptoms related to carotid atherosclerosis in nondiabetic conditions. Materials and methods We evaluated plasma levels of CML and sRAGE (by ELISA), and tissue levels (tAGEs and tRAGE, semiquantitatively, by immunohistochemistry) in endarterectomy carotid plaque tissue in 29 nondiabetic patients. At the time of surgery, 10 patients were asymptomatic and 19 were symptomatic. Results Plasma levels of sRAGE were higher in symptomatic patients than in asymptomatic patients [median (interquartile range): 676 (394-858) pg mL‾ overline1 vs. 347 (284-479) pg mL‾ overline1, P = 0.009]. In symptomatic patients, plasma levels of sRAGE correlated positively with CML (r = 0.60, P 0.01), C-reactive protein (CRP) (r (literal)

Prodotto di

• Istituto di fisiologia clinica (IFC) (Istituto)
• MEDICINA TRASLAZIONALE (ME.P05.016.001) (Modulo)

Autore CNR

• SERENA DEL TURCO (Persona)
• GIUSEPPINA BASTA (Persona)

Insieme di parole chiave

• Parole chiave di "High plasma levels of the soluble receptor for advanced glycation endproducts in patients with symptomatic carotid atherosclerosis" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)
• MEDICINA TRASLAZIONALE (ME.P05.016.001) (Modulo)

Autore CNR di

• GIUSEPPINA BASTA (Persona)
• SERENA DEL TURCO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European journal of clinical investigation (Rivista)

Insieme di parole chiave di

• Parole chiave di "High plasma levels of the soluble receptor for advanced glycation endproducts in patients with symptomatic carotid atherosclerosis" (Insieme di parole chiave)