Gene expression profiles of apoptotic neurons (Articolo in rivista)

Type
Label
  • Gene expression profiles of apoptotic neurons (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Alternative label
  • Cavallaro S., D'Agata V., Alessi E., Coffa S., Alkon D.L., Manickam P., Ciotti M.T., Possenti R., Bonini P., Marlier L., Calissano P. (2004)
    Gene expression profiles of apoptotic neurons
    in Genomics (S. Diego Calif.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cavallaro S., D'Agata V., Alessi E., Coffa S., Alkon D.L., Manickam P., Ciotti M.T., Possenti R., Bonini P., Marlier L., Calissano P. (literal)
Pagina inizio
  • 485 (literal)
Pagina fine
  • 496 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 84 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a Institute of Neurological Sciences, Italian National Research Council, 95123 Catania, Italy b STMicroelectronics, Catania, Italy c Blanchette Rockefeller Neurosciences Institute, West Virginia University, Rockville, MD 20850, USA d Capital Genomix, Inc., Rockville, MD 20850, USA e Institute of Neurobiology and Molecular Medicine, Italian National Research Council, 00137 Rome, Italy (literal)
Titolo
  • Gene expression profiles of apoptotic neurons (literal)
Abstract
  • The multigenic program underlying neuronal apoptosis is mostly unknown. To study the program, we used genome-scale screening by oligonucleotide microarrays during serum and potassium deprivation-induced apoptosis of cerebellar granule neurons. From the 8740 genes interrogated by the arrays, 423 genes were found to be regulated at both the transcriptional and the posttranscriptional level and segregated into distinct clusters. Semantic clustering based on gene ontologies showed coordinated expression of genes with common biological functions and metabolic pathways. Among the genes implicated in apoptotic cerebellar granule neurons, 70 were in common with those differentially expressed in cortical neurons exposed to amyloid h-protein, indicating the existence of common mechanisms responsible for neuronal cell death. Our results offer a genomic view of the changes that accompany neuronal apoptosis and yield new insights into the underlying molecular basis. (literal)
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