Induction of ETS-1 and ETS-2 transcription factors is required for thyroid cell transformation (Articolo in rivista)

Type
Label
  • Induction of ETS-1 and ETS-2 transcription factors is required for thyroid cell transformation (Articolo in rivista) (literal)
Anno
  • 2001-01-01T00:00:00+01:00 (literal)
Alternative label
  • De Nigris, F. Mega, T. Berger, N. Barone, M. V. Santoro, M. Viglietto, G. Verde, P. Fusco, A. (2001)
    Induction of ETS-1 and ETS-2 transcription factors is required for thyroid cell transformation
    in Cancer research (Chic. Ill.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • De Nigris, F. Mega, T. Berger, N. Barone, M. V. Santoro, M. Viglietto, G. Verde, P. Fusco, A. (literal)
Pagina inizio
  • 2267 (literal)
Pagina fine
  • 2275 (literal)
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  • Impact Factor = 8,302 Interdisciplinarietà del prodotto: The Authors belong to different scientific areas, sectors and Istitutions. The paper was in collaboration with International Institutions. (literal)
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  • 61 (literal)
Rivista
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  • The proteins of the Ets family are transcription factors involved in signal transduction, cell cycle progression, and differentiation. In this study, we report that thyroid cell neoplastic transformation is associated with a dramatic increase in ETS transcriptional activity, which is dependent on the accumulation of Ets-1, Ets-2, and other Ets-related proteins. Inhibition of ETS transactivation activity by the Ets-dominant negative construct (Ets-Z) induced programmed cell death in human thyroid carcinoma cell lines but not in normal thyroid cells. Apoptotic cell death induced by Ets-Z was dependent on the reduction of c-MYC protein levels, because it was prevented by overexpression of c-myc. Taken together, these data indicate that the induction of Ets-1 and Ets-2 transcription factors plays a pivotal role in thyroid cell neoplastic transformation. (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • 1 Centro di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università degli Studi di Napoli, Italy; 2 Istituto Internazionale di Genetica e Biofisica CNR, Naples, Italy; 3 Laboratoire d’Anatomie Pathologique, Hopital de L’Antiquaille, Lyon, France; 4 INT di Napoli, Fondazione Senatore Pascale, Naples, Italy; 5 Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Catanzaro, Italy (literal)
Titolo
  • Induction of ETS-1 and ETS-2 transcription factors is required for thyroid cell transformation (literal)
Abstract
  • The proteins of the Ets family are transcription factors involved in signal transduction, cell cycle progression, and differentiation. In this study, we report that thyroid cell neoplastic transformation is associated with a dramatic increase in ETS transcriptional activity, which is dependent on the accumulation of Ets-1, Ets-2, and other Ets-related proteins. Inhibition of ETS transactivation activity by the Ets-dominant negative construct (Ets-Z) induced programmed cell death in human thyroid carcinoma cell lines but not in normal thyroid cells. Apoptotic cell death induced by Ets-Z was dependent on the reduction of c-MYC protein levels, because it was prevented by overexpression of c-myc. Taken together, these data indicate that the induction of Ets-1 and Ets-2 transcription factors plays a pivotal role in thyroid cell neoplastic transformation. (literal)
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