http://www.cnr.it/ontology/cnr/individuo/prodotto/ID167570
Histomorphometric, ultrastructural and microhardness evaluation of the osseoiuntegration of a nanostructured titanium oxide coating by Metal-Organic Chemical Vapour Deposition: an in vivo study (Articolo in rivista)
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- Histomorphometric, ultrastructural and microhardness evaluation of the osseoiuntegration of a nanostructured titanium oxide coating by Metal-Organic Chemical Vapour Deposition: an in vivo study (Articolo in rivista) (literal)
- Anno
- 2004-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.biomaterials.2004.01.017 (literal)
- Alternative label
Gianluca Giavaresi; Luigi Ambrosio; Giovanni A. Battiston; Umberto Casellato; Rosalba Gerbasi; Milena Fini; Nicolò Nicoli Aldini; Lucia Martini; Lia Rimondini; Roberto Giardino (2004)
Histomorphometric, ultrastructural and microhardness evaluation of the osseoiuntegration of a nanostructured titanium oxide coating by Metal-Organic Chemical Vapour Deposition: an in vivo study
in Biomaterials; Academic Press Elsevier, Amsterdam (Paesi Bassi)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Gianluca Giavaresi; Luigi Ambrosio; Giovanni A. Battiston; Umberto Casellato; Rosalba Gerbasi; Milena Fini; Nicolò Nicoli Aldini; Lucia Martini; Lia Rimondini; Roberto Giardino (literal)
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- Subject Category: Materials Science; Biomaterials (literal)
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- http://www.sciencedirect.com/science/article/pii/S0142961204000559 (literal)
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- 1-6-7-8: Department of Experimental Surgery, Research Institute \"Codivilla-Putti\", Rizzoli Orthopaedic Institute, Bologna, Italy /
2: Institute of Composite and Biomedical Materials, CNR, Naples, Italy /
3-4-5: Institute of Inorganic Chemistry and Surfaces, National Research Council, Padova, Italy /
9: Department of Experimental Surgery, Research Institute \"Codivilla-Putti\", Rizzoli Orthopaedic Institute, Bologna, Italy - Faculty of Medicine, University of Bologna, Bologna, Italy (literal)
- Titolo
- Histomorphometric, ultrastructural and microhardness evaluation of the osseoiuntegration of a nanostructured titanium oxide coating by Metal-Organic Chemical Vapour Deposition: an in vivo study (literal)
- Abstract
- Over the past decade the increase of elderly population has determined a rise in the incidence of bone fractures, and the improvement of the implant-bone interface remains an open problems. Metal-Organic Chemical Vapour Deposition (MOCVD) has recently been proposed as a technique to coat orthopaedic and dental prostheses with metal nanostructured oxide films either through the decomposition of oxygenated compounds (single-source precursors) or the reaction of oxygen-free metal compounds with oxygenating agents. The present study was performed to assess the in vivo biocompatibility of commercially pure Ti (control material: TI/MA) implants (w 2 mm x 5 mm length) coated with nanostructured TiO2 film by MOCVD (Ti/MOCVD) and then inserted into rabbit femoral cortical (middhiaphysis) and cancellous (distal epiphysis) bone. Histomorphometric, ultrastructural and microhardness investigations were carried out. Four and 12 weeks after surgery, significant (p < 0.0005) increases in AI of Ti/MOCVD implants were observed as compared to Ti/MA implants (distal femoral epiphysis: 4 weeks= 8.2%, ns; 12 weeks= 52.3%, p < 0.005; femoral diaphysis: 4 weeks= 20.2%, p < 0.0005; 12 weeks= 10.7%, p < 0.005). Bone microhardness results showed significant increases for the Ti/MOCVD versus Ti/MA implants at 200 mm in the femoral diaphysis (4 weeks= 14.2, p < 0.005) and distal femoral epiphysis (12 weeks= 14.5, p < 0.01) at 4 and 12 weeks, respectively. In conclusion, the current findings demonstrate that the nanostructured TiO2 coating positively affects the osteointegration rate of commercially pure Ti implants and the bone mineralization at the bone-biomaterial interface in both cortical and cancellous bone. (literal)
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