TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1073/pnas.0606102103 (literal)

Alternative label

• Bartolomucci A; La Corte G; Possenti R; Locatelli V; Rigamonti AE; Torsello A; Bresciani E; Bulgarelli I; Rizzi R; Pavone F; D'Amato FR; Severini C; Mignogna G; Giorgi A; Schinina ME; Elia G; Brancia C; Ferri GL; Conti R; Pascucci T; Dell'Omo G; Levi A; Moles A (2006)
  TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity
  in Proceedings of the National Academy of Sciences of the United States of America
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bartolomucci A; La Corte G; Possenti R; Locatelli V; Rigamonti AE; Torsello A; Bresciani E; Bulgarelli I; Rizzi R; Pavone F; D'Amato FR; Severini C; Mignogna G; Giorgi A; Schinina ME; Elia G; Brancia C; Ferri GL; Conti R; Pascucci T; Dell'Omo G; Levi A; Moles A (literal)

Pagina inizio

• 14584 (literal)

Pagina fine

• 14589 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact Factor = 9.643 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 103 (literal)

Rivista

• Proceedings of the National Academy of Sciences of the United States of America (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• * Brancia C.17, Ferri G.L.18, Conti R.19, Ciani B.20, Pascucci T.21, Dell'Omo G.22, Muller E.E.23, Levi A.24, Moles A.25 1,10,11,25 = Institute of Neuroscience, CNR, 00143 Rome, Italy; 2,3,12,24 = INMM, CNR, 00143 Rome, Italy; 3,9 = Dep. of Neuroscience, Univ.of Roma II–Tor Vergata, 00161 Rome, Italy; 4,6,7,8 = Dep. of Experimental and Environmental Medicine and Biotechnology and Interdepartmental Center for Bioinformatics and Proteomics, Univ. of Milan–Bicocca, 20052 Monza, Italy; 5,23 = Dep. of Pharmacology, Chemotherapy, and Medical Toxicology, Univ.of Milan, 20129 Milan, Italy; 13,14,15 = Dep. of Biochemical Science, Univ. \"La Sapienza,\" 00185 Rome, Italy; 16 = Dep.of Chemistry and Applied Biosciences, Inst.of Pharmaceutical Sciences, CH-8093 Zürich, Switzerland; 17,18 = NEF Laboratory, Dep.of Cytomorphology, Univ. of Cagliari, 09042 Monserrato, Italy; 19,20 = Dep. of Endocrinology and Metabolism, Sigma-Tau Pharmaceuticals Industries S.p.A., 00040 Rome, Italy; 21 = Foundation Santa Lucia, 00143 Rome, Italy; 22 = Inst. of Anatomy and Center for Neuroscience, Univ. of Zürich, CH-8057 Zürich, Switzerland. (literal)

Titolo

• TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity (literal)

Abstract

• The vgf gene has been identified as an energy homeostasis regulator. Vgf encodes a 617-aa precursor protein that is processed to yield an incompletely characterized panel of neuropeptides. Until now, it was an unproved assumption that VGF-derived peptides could regulate metabolism. Here, a VGF peptide designated TLQP-21 was identified in rat brain extracts by means of immunoprecipitation, microcapillary liquid chromatography-tandem MS, and database searching algorithms. Chronic intracerebroventricular (i.c.v.) injection of TLQP-21 (15 mug/day for 14 days) increased resting energy expenditure (EE) and rectal temperature in mice. These effects were paralleled by increased epinephrine and up-regulation of brown adipose tissue beta2-AR (beta2 adrenergic receptor) and white adipose tissue (WAT) PPAR-delta (peroxisome proliferator-activated receptor delta), beta3-AR, and UCP1 (uncoupling protein 1) mRNAs and were independent of locomotor activity and thyroid hormones. Hypothalamic gene expression of orexigenic and anorexigenic neuropeptides was unchanged. Furthermore, in mice that were fed a high-fat diet for 14 days, TLQP-21 prevented the increase in body and WAT weight as well as hormonal changes that are associated with a high-fat regimen. Biochemical and molecular analyses suggest that TLQP-21 exerts its effects by stimulating autonomic activation of adrenal medulla and adipose tissues. In conclusion, we present here the identification in the CNS of a previously uncharacterized VGF-derived peptide and prove that its chronic i.c.v. infusion effected an increase in EE and limited the early phase of diet-induced obesity. (literal)

Prodotto di

• Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)
• Patologie del S.N. e Fattori di Crescita (ME.P02.010.001) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• ANDREA LEVI (Persona)
• FRANCESCA ROMANA D'AMATO (Persona)
• GIULIANO ELIA (Unità di personale interno)
• ANNA MOLES (Unità di personale interno)
• CINZIA SEVERINI (Persona)
• FLAMINIA PAVONE (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANDREA LEVI (Persona)
• GIULIANO ELIA (Unità di personale interno)
• ANNA MOLES (Unità di personale interno)
• CINZIA SEVERINI (Persona)
• FLAMINIA PAVONE (Unità di personale interno)
• FRANCESCA ROMANA D'AMATO (Persona)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.001) (Modulo)
• Patologie del S.N. e Fattori di Crescita (ME.P02.010.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Proceedings of the National Academy of Sciences of the United States of America (Rivista)

Insieme di parole chiave di

• Parole chiave di "TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity" (Insieme di parole chiave)