Choline pivaloyl ester enhances brain expression of both nerve growth factor and high-affinity receptor TrkA, and reverses memory and cognitive deficits, in rats with excitotoxic lesion of nucleus basalis magnocellularis. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Choline pivaloyl ester enhances brain expression of both nerve growth factor and high-affinity receptor TrkA, and reverses memory and cognitive deficits, in rats with excitotoxic lesion of nucleus basalis magnocellularis. (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Rispoli V., Marra R., Costa N., Rotiroti D., Tirassa P., Scipione L., De Vita D., Liberatore F., Carelli V. (2008)
  Choline pivaloyl ester enhances brain expression of both nerve growth factor and high-affinity receptor TrkA, and reverses memory and cognitive deficits, in rats with excitotoxic lesion of nucleus basalis magnocellularis.
  in Behavioural brain research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Rispoli V., Marra R., Costa N., Rotiroti D., Tirassa P., Scipione L., De Vita D., Liberatore F., Carelli V. (literal)

Pagina inizio

• 22 (literal)

Pagina fine

• 32 (literal)

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• Epub 2008 Feb 8. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 190 (literal)

Rivista

• Behavioural brain research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• Il lavoro descrive lo studio di efficacia di nuovi farmaci utili nel contrastare i sintomi cognitivi della malattia di Alzheimer (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• V.Rispoli, N.Costa, Università degli Studi di Catanzaro D.Rotiroti, R.Marra: ISN CNR P.Tirassa, L.Scipione, D.De Vita, F.Liberatore, V.Carelli: Università degli Studi di Roma La Sapienza (literal)

Titolo

• Choline pivaloyl ester enhances brain expression of both nerve growth factor and high-affinity receptor TrkA, and reverses memory and cognitive deficits, in rats with excitotoxic lesion of nucleus basalis magnocellularis. (literal)

Abstract

• The aim of present work was the evaluation of the effects on brain levels of nerve growth factor (NGF) and of its high-affinity tyrosine kinase A receptor (TrkA), induced in rats unilaterally lesioned at nucleus basalis magnocellularis (NBM), by treatment with choline pivaloyl ester (CPE). CPE was daily administered (60mumol/Kg ip) during 3 weeks to rats selectively lesioned by AMPA infusion into right NBM; the intact left NBM serving as control. NGF levels were determined in cerebral cortex and hippocampus by Elisa assay. TrkA receptor expression was evaluated in right NBM by Western blotting analysis. CPE treatment significantly increased NGF levels in both hippocampus and neocortex in right NBM, compared with intact left counter-part and controls. Western blotting showed an evident enhancement in TrkA receptor expression in lesioned right NBM in comparison with intact left counter-part and controls. CPE treatment was also able to restore, in bilaterally NBM-lesioned rats, the disrupted cortical EEG and HVS activities as well as to reverse deficits in learning and memory in spatial navigation and probe trials, and cognitive capacities in object recognition task. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Farmacologia delle malattie ereditarie del sistema nervoso (ME.P02.014.001) (Modulo)
• Institute of neurological sciences (ISN) (Istituto)

Autore CNR

• ROSARIO MARRA (Persona)
• PAOLA TIRASSA (Unità di personale interno)
• DOMENICANTONIO ROTIROTI (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Choline pivaloyl ester enhances brain expression of both nerve growth factor and high-affinity receptor TrkA, and reverses memory and cognitive deficits, in rats with excitotoxic lesion of nucleus basalis magnocellularis." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• DOMENICANTONIO ROTIROTI (Unità di personale esterno)
• PAOLA TIRASSA (Unità di personale interno)
• ROSARIO MARRA (Persona)

Prodotto

• Institute of neurological sciences (ISN) (Istituto)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Farmacologia delle malattie ereditarie del sistema nervoso (ME.P02.014.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Behavioural brain research (Rivista)

Insieme di parole chiave di

• Keywords of "Choline pivaloyl ester enhances brain expression of both nerve growth factor and high-affinity receptor TrkA, and reverses memory and cognitive deficits, in rats with excitotoxic lesion of nucleus basalis magnocellularis." (Insieme di parole chiave)