Chronic intracerebroventricular TLQP-21 delivery does not modulate the GH/IGF-1-axis and muscle strength in mice. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Chronic intracerebroventricular TLQP-21 delivery does not modulate the GH/IGF-1-axis and muscle strength in mice. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• Bartolomucci A.1, Rigamonti A.E.2, Bulgarelli I.3, Torsello A.4, Locatelli V.5, Pavone F.6, Levi A.7, Possenti R.8, Muller E.E.9, Moles A.10 (2007)
  Chronic intracerebroventricular TLQP-21 delivery does not modulate the GH/IGF-1-axis and muscle strength in mice.
  in Growth hormone & IGF research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bartolomucci A.1, Rigamonti A.E.2, Bulgarelli I.3, Torsello A.4, Locatelli V.5, Pavone F.6, Levi A.7, Possenti R.8, Muller E.E.9, Moles A.10 (literal)

Pagina inizio

• 342 (literal)

Pagina fine

• 345 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact factor = 2.183 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 17/4 (literal)

Rivista

• Growth hormone & IGF research (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1,6,10 = Institute of Neuroscience, CNR, Rome, Italy; 2,9 = Department of Pharmacology, Chemoterapy and Medical Toxicology, University of Milano, Italy; 3,4,5 = Department of Experimental and Environmental Medicine and Biotechnology, and Interdipartimental Center for Bioinformathics and Proteomics, University of Milano-Bicocca, Monza, Italy; 7,8 = Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy; 8 = Department of Neuroscience, University of Roma II, Tor Vergata, Rome, Italy (literal)

Titolo

• Chronic intracerebroventricular TLQP-21 delivery does not modulate the GH/IGF-1-axis and muscle strength in mice. (literal)

Abstract

• OBJECTIVE: Biallelic ablation of VGF determines a dwarf phenotype. VGF precursor protein encodes for different biologically active peptides none of which has been related to growth or muscular abnormalities. Here we present the first attempt to fill this gap. We tested the hypothesis that a recently identified VGF-derived peptide, TLQP-21, shown to centrally modulate metabolic functions, could also modulate growth hormone (GH)-axis and muscle strength. DESIGN: Adult male mice were chronically icv injected with TLQP-21 (15mug/day for 14 days). Physiological, molecular and behavioral parameters related to the GH/IGF-1-axis were investigated. RESULTS: Except for a reduction in the soleus weight, TLQP-21 did not affect GH/IGF-1-axis mediators, muscle strength and muscle weight. CONCLUSIONS: Results collected exclude a role for TLQP-21 in modulating the GH/IGF1-axis and muscle functions. VGF-derived peptides involved in the dwarf phenotype of VGF-/- mice have to be identified yet. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Istituto di neuroscienze (IN) (Istituto)
• Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.001) (Modulo)
• Sviluppo, Differenziamento e Trasformazione Cellulare (SV.P15.006.001) (Modulo)

Autore CNR

• Roberta Possenti (Persona)
• ANNA MOLES (Unità di personale interno)
• ANDREA LEVI (Persona)
• FLAMINIA PAVONE (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Chronic intracerebroventricular TLQP-21 delivery does not modulate the GH/IGF-1-axis and muscle strength in mice." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANDREA LEVI (Persona)
• ANNA MOLES (Unità di personale interno)
• FLAMINIA PAVONE (Unità di personale interno)
• Roberta Possenti (Persona)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.001) (Modulo)
• Sviluppo, Differenziamento e Trasformazione Cellulare (SV.P15.006.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Growth hormone & IGF research (Rivista)

Insieme di parole chiave di

• Parole chiave di "Chronic intracerebroventricular TLQP-21 delivery does not modulate the GH/IGF-1-axis and muscle strength in mice." (Insieme di parole chiave)