http://www.cnr.it/ontology/cnr/individuo/prodotto/ID167405
Inhibition of rat glioma cell migration and proliferation by a calix[8]arene scaffold exposing multiple GlcNAc and ureido functionalities (Articolo in rivista)
- Type
- Label
- Inhibition of rat glioma cell migration and proliferation by a calix[8]arene scaffold exposing multiple GlcNAc and ureido functionalities (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1111/j.1471-4159.2008.05656.x (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Viola S.; Consoli G. M. L.; Merlo S.; Drago F.; Sortino M. A.; Geraci C. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Scopu (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Department of Experimental and Clinical Pharmacology, University of Catania, Viale Andrea Doria, Catania, Italy
Istituto di Chimica Biomolecolare, C.N.R. Valverde, CT, Italy
DISCAFF, University of Piemonte Orientale, Novara, Italy (literal)
- Titolo
- Inhibition of rat glioma cell migration and proliferation by a calix[8]arene scaffold exposing multiple GlcNAc and ureido functionalities (literal)
- Abstract
- b1,4-Galactosyltransferases (b1,4-GalTase) exposed on the
cell surface are involved in cell migration. Specifically, b1,4-
GalTase V is highly expressed in glioma and promotes invasion,
growth, and survival of glioma cells. A glycocalix[8]arene
exposing N-acetylglucosamine (GlcNAc) residues (compound
1) inhibited rat C6 glioma cell migration as assessed in a
scratch wound model. This effect was related to inhibition of
focal adhesion kinase phosphorylation, measured by western
blot analysis, and specifically observed in the area bordering
the scratch wound. Compound 1 inhibited also C6 cell proliferation,
an effect unrelated to its ability to interact with Gal-
Tase as it was mimicked by different calix[8]arene derivatives,
all characterized by multivalency and ureido groups. Compound
1 did not induce apoptotic death, but caused a different
distribution of C6 cells within the cell cycle. The results here
reported identify compound 1 as a molecule able to exert
inhibitory effects on C6 cell migration and proliferation, independently,
because of distinct components in its structure. (literal)
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