http://www.cnr.it/ontology/cnr/individuo/prodotto/ID167334
Pt(II) and Pd(II) derivatives of ter-butylsarcosinedithiocarbamate: Synthesis, chemical and biological characterization and in vitro nephrotoxicity (Articolo in rivista)
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- Pt(II) and Pd(II) derivatives of ter-butylsarcosinedithiocarbamate: Synthesis, chemical and biological characterization and in vitro nephrotoxicity (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Alternative label
Fregona, D. 1; Giovagnini, L. 1; Ronconi, L. 1; Marzano, C. 2; Trevisan, A. 3; Sitran, S. 4; Biondi, B. 5; Bordin, F. 2 (2003)
Pt(II) and Pd(II) derivatives of ter-butylsarcosinedithiocarbamate: Synthesis, chemical and biological characterization and in vitro nephrotoxicity
in Journal of inorganic biochemistry
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- Fregona, D. 1; Giovagnini, L. 1; Ronconi, L. 1; Marzano, C. 2; Trevisan, A. 3; Sitran, S. 4; Biondi, B. 5; Bordin, F. 2 (literal)
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- 1. University Department of Inorganic, Metallorganic and Analytical Chemistry,Padova
2. University Department of Pharmaceutical Sciences, Padova
3. University Department of Environmental Medicine and Public Health, Padova
4. Institute of Chemistry and Inorganic Technologies and Advanced Materials, C.N.R., Padova
5. Biopolymers Research Centre, C.N.R., Padova (literal)
- Titolo
- Pt(II) and Pd(II) derivatives of ter-butylsarcosinedithiocarbamate: Synthesis, chemical and biological characterization and in vitro nephrotoxicity (literal)
- Abstract
- This work reports on the synthesis, characterization and biological activity of new coordination compounds of the type [M(TSDTM)X2] (M=Pt(II), Pd(II); X=Cl, Br; TSDTM=ter-butylsarcosine(S-methyl)dithiocarbamate) and [Pd(TSDT)X]n (TSDT=ter-butylsarcosinedithiocarbamate) in order to study their behavior as potential antitumor agents. All the synthesized compounds were characterized by means of elemental analysis, FT-IR, 1H and 13C-NMR spectroscopy and thermogravimetric analysis, suggesting a chelate S,S' structure of the TSDTM/TSDT ligand in a square-planar geometry. Finally, the synthesized complexes have been tested for in vitro cytotoxic activity against human leukemic HL60 and adenocarcinoma HeLa cells; the most active compound [Pt(TSDTM)Br2], characterized by IC50 values very similar to those of the reference compound (cisplatin), was also tested for in vitro nephrotoxicity showing a very low renal cytotoxicity as compared to cisplatin itself. (literal)
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