Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1177/1352458508098270 (literal)

Alternative label

• Tedeschi G; Dinacci D; Comerci M; Lavorgna L; Savettieri G; Quattrone A; Livrea P; Patti F; Morra VB; Servillo G; Orefice G; Paciello M; Prinster A; Coniglio G; Bonavita S; Di Costanzo A; Bellacosa A; Valentino P; Quarantelli M; Brunetti A; Salemi G; D'Am (2008)
  Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study
  in Multiple sclerosis
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Tedeschi G; Dinacci D; Comerci M; Lavorgna L; Savettieri G; Quattrone A; Livrea P; Patti F; Morra VB; Servillo G; Orefice G; Paciello M; Prinster A; Coniglio G; Bonavita S; Di Costanzo A; Bellacosa A; Valentino P; Quarantelli M; Brunetti A; Salemi G; D'Am (literal)

Pagina inizio

• 204 (literal)

Pagina fine

• 211 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 15 (literal)

Rivista

• Multiple sclerosis (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Univ Naples 2, Dept Neurol Sci, I-80138 Naples, Italy Inst Hermitage Capodimonte, Naples, Italy CNR, Inst Biostruct & Bioimaging, Naples, Italy Univ Palermo, Dept Neurol, Palermo, Italy Univ Catanzaro, Dept Neurol, Catanzaro, Italy Univ Bari, Dept Neurol & Psychiat Sci, Bari, Italy Univ Catania, Dept Neurol, Catania, Italy Univ Naples Federico 2, Dept Neurol Sci, Naples, Italy San Carlo Hosp, Dept Neurol, Potenza, Italy Univ Naples Federico 2, Dept Diagnost Imaging, Naples, Italy (literal)

Titolo

• Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study (literal)

Abstract

• BackgroundTo investigate in a large cohort of patients with multiple sclerosis (MS), lesion load and atrophy evolution, and the relationship between clinical and magnetic resonance imaging (MRI) correlates of disease progression.MethodsTwo hundred and sixty-seven patients with MS were studied at baseline and two years later using the same MRI protocol. Abnormal white matter fraction, normal appearing white matter fraction, global white matter fraction, gray matter fraction and whole brain fraction, T2-hyperintense, and T1-hypointense lesions were measured at both time points.ResultsThe majority of patients were clinically stable, whereas MRI-derived brain tissue fractions were significantly different after 2 years. The correlation between MRI data at baseline and their variation during the follow-up showed that lower basal gray matter atrophy was significantly related with higher progression of gray matter atrophy during follow-up. The correlation between MRI parameters and disease duration showed that gray matter atrophy rate decreased with increasing disease duration, whereas the rate of white matter atrophy had a constant pattern. Lower basal gray matter atrophy was associated with increased probability of developing gray matter atrophy at follow-up, whereas gray matter atrophy progression over 2 years and new T2 lesion load were risk factors for whole brain atrophy progression.ConclusionsIn MS, brain atrophy occurs even after a relatively short period of time and in patients with limited progression of disability. Short-term brain atrophy progression rates differ across tissue compartments, as gray matter atrophy results more pronounced than white matter atrophy and appears to be a early phenomenon in the MS-related disease progression. (literal)

Prodotto di

• Institute of neurological sciences (ISN) (Istituto)
• Messa a punto di Metodiche Diagnostiche innovative di Imaging Quantitativo (ME.P06.004.002) (Modulo)
• Institute of biostructure and bioimaging (IBB) (Istituto)
• Diagnostica avanzata delle malattie ereditarie del sistema nervoso (ME.P02.012.001) (Modulo)

Autore CNR

• ALDO QUATTRONE (Unità di personale esterno)
• MARCO SALVATORE (Persona)
• ANNA PRINSTER (Unità di personale interno)
• BRUNO ALFANO (Unità di personale interno)
• MARCO COMERCI (Persona)
• ARTURO BRUNETTI (Unità di personale esterno)
• MARIO QUARANTELLI (Persona)

Insieme di parole chiave

• Keywords of "Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIO QUARANTELLI (Persona)
• ARTURO BRUNETTI (Unità di personale esterno)
• ALDO QUATTRONE (Unità di personale esterno)
• MARCO SALVATORE (Persona)
• ANNA PRINSTER (Unità di personale interno)
• BRUNO ALFANO (Unità di personale interno)
• MARCO COMERCI (Persona)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Institute of neurological sciences (ISN) (Istituto)
• Messa a punto di Metodiche Diagnostiche innovative di Imaging Quantitativo (ME.P06.004.002) (Modulo)
• Diagnostica avanzata delle malattie ereditarie del sistema nervoso (ME.P02.012.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Multiple sclerosis (Rivista)

Insieme di parole chiave di

• Keywords of "Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study" (Insieme di parole chiave)