http://www.cnr.it/ontology/cnr/individuo/prodotto/ID167310

Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons (Articolo in rivista) (literal)

Anno

2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1523/JNEUROSCI.3502-04.2004 (literal)

Alternative label

Miriam Melis (1,2); Simona Perra (1,2); Anna Lisa Muntoni (1,3); Giuliano Pillolla (1,2); Beat Lutz (4); Giovanni Marsicano (4); Vincenzo Di Marzo, (5); Gian Luigi Gessa (1,2); Marco Pistis (1,2) (2004)
Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons
in The Journal of neuroscience
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Miriam Melis (1,2); Simona Perra (1,2); Anna Lisa Muntoni (1,3); Giuliano Pillolla (1,2); Beat Lutz (4); Giovanni Marsicano (4); Vincenzo Di Marzo, (5); Gian Luigi Gessa (1,2); Marco Pistis (1,2) (literal)

Pagina inizio

10707 (literal)

Pagina fine

10715 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

24 (literal)

Rivista

?The ?Journal of neuroscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

47 (literal)

Note

PubMe (literal)
ISI Web of Science (WOS) (literal)
Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

(1) Center of Excellence Neurobiology of Addiction, University of Cagliari, Monserrato, Italy (2) B. B. Brodie Department of Neuroscience, University of Cagliari, Monserrato, Italy (3) CNR Institute of Neuroscience, University of Cagliari, Monserrato, Italy (4) Group Molecular Genetics of Behavior, Max Planck Institute of Psychiatry, Munich, Germany (5) CNR Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Pozzuoli, Italy (literal)

Titolo

Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons (literal)

Abstract

Endocannabinoids form a novel class of retrograde messengers that modulate short- and long-term synaptic plasticity. Depolarizationinduced suppression of excitation (DSE) and inhibition (DSI) are the best characterized transient forms of endocannabinoid-mediated synaptic modulation. Stimulation protocols consisting of long-lasting voltage steps to the postsynaptic cell are routinely used to evoke DSE-DSI. Little is known, however, about more physiological conditions under which these molecules are released in vitro. Moreover, the occurrence in vivo of such forms of endocannabinoid-mediated modulation is still controversial. Here we show that physiologically relevant patterns of synaptic activity induce a transient suppression of excitatory transmission onto dopamine neurons in vitro. Accordingly, in vivo endocannabinoids depress the increase in firing and bursting activity evoked in dopamine neurons by prefrontal cortex stimulation. This phenomenon is selectively mediated by the endocannabinoid 2-arachidonoyl-glycerol (2-AG), which activates presynaptic cannabinoid type 1 receptors. 2-AG synthesis involves activation of metabotropic glutamate receptors and Ca2++ mobilization from intracellular stores. These findings indicate that dopamine neurons release 2-AG to shape afferent activity and ultimately their own firing pattern. This novel endocannabinoid-mediated self-regulatory role of dopamine neurons may bear relevance in the pathogenesis of neuropsychiatric disorders such as schizophrenia and addiction. (literal)

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