DNA vaccination strategies for anti-tumour effective gene therapy protocols (Articolo in rivista)

Type
Label
  • DNA vaccination strategies for anti-tumour effective gene therapy protocols (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/s00262-010-0853-x (literal)
Alternative label
  • Signori E 1,2; Iurescia S 1; Massi E 1,2; Fioretti D 1; Chiarella P 1,2; De Robertis M 1,2; Rinaldi M 1; Tonon G 3; Fazio VM. 2 (2010)
    DNA vaccination strategies for anti-tumour effective gene therapy protocols
    in Cancer immunology, immunotherapy (Internet)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Signori E 1,2; Iurescia S 1; Massi E 1,2; Fioretti D 1; Chiarella P 1,2; De Robertis M 1,2; Rinaldi M 1; Tonon G 3; Fazio VM. 2 (literal)
Pagina inizio
  • 1583 (literal)
Pagina fine
  • 1591 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • This paper is a Focussed Research Review based on a presentation given at the Ninth International Conference on Progress in Vaccination against Cancer (PIVAC 9), held in Sofia, Bulgaria, 8–10 October 2009. S. Iurescia, E. Massi, D. Fioretti, P. Chiarella and M. De Robertis are joint second authors and have contributed equally to this paper. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 59 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • 2010 Apr 14. [Epub ahead of print] (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 10 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 - CNR-Institute of Neurobiology and Molecular Medicine, Via Fosso del Cavaliere 100, 00133 Rome, Italy; 2 - Section of Molecular Medicine and Biotechnology, PRABB, Centre of Integrated Research, Università Campus Bio-Medico di Roma, Via A. del Portillo 21, 00128 Rome, Italy; 3 - Bio-ker S.r.l., POLARIS, Località Piscinamanna, 09010 Pula, Cagliari, Italy. (literal)
Titolo
  • DNA vaccination strategies for anti-tumour effective gene therapy protocols (literal)
Abstract
  • After more than 15 years of experimentation, DNA vaccines have become a promising perspective for tumour diseases, and animal models are widely used to study the biological features of human cancer progression and to test the efficacy of vaccination protocols. In recent years, immunisation with naked plasmid DNA encoding tumour-associated antigens or tumour-specific antigens has revealed a number of advantages: antigen-specific DNA vaccination stimulates both cellular and humoral immune responses; multiple or multi-gene vectors encoding several antigens/determinants and immune-modulatory molecules can be delivered as single administration; DNA vaccination does not induce autoimmune disease in normal animals; DNA vaccines based on plasmid vectors can be produced and tested rapidly and economically. However, DNA vaccines have shown low immunogenicity when tested in human clinical trials, and compared with traditional vaccines, they induce weak immune responses. Therefore, the improvement of vaccine efficacy has become a critical goal in the development of effective DNA vaccination protocols for anti-tumour therapy. Several strategies are taken into account for improving the DNA vaccination efficacy, such as antigen optimisation, use of adjuvants and delivery systems like electroporation, co-expression of cytokines and co-stimulatory molecules in the same vector, different vaccination protocols. In this review we discuss how the combination of these approaches may contribute to the development of more effective DNA vaccination protocols for the therapy of lymphoma in a mouse model. (literal)
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