http://www.cnr.it/ontology/cnr/individuo/prodotto/ID167254

Identification by [99mTc]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinsons disease (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Identification by [99mTc]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinsons disease (Articolo in rivista) (literal)

Anno

2007-01-01T00:00:00+01:00 (literal)

Alternative label

Varrone A; Pagani M; Salvatore E; Salmaso D; Sansone V; Amboni M; Nobili F; De Michele G; Filla A; Barone P; Pappata S; Salvatore M. (2007)
Identification by [99mTc]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinsons disease
in European journal of nuclear medicine and molecular imaging (Print)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Varrone A; Pagani M; Salvatore E; Salmaso D; Sansone V; Amboni M; Nobili F; De Michele G; Filla A; Barone P; Pappata S; Salvatore M. (literal)

Pagina inizio

1071 (literal)

Pagina fine

1081 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

34 (literal)

Rivista

European journal of nuclear medicine and molecular imaging (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

DOI 10.1007/s00259-006-0344-7 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Biostructure and Bioimaging Institute, National Research Council; Department of Biomorphological and Functional Sciences, University Federico II, Napoli, Italy ISTC, Institute of Cognitive Sciences and Technologies, National Research Council, Rome and Padua, Italy Department of Neurological Sciences, University Federico II, Napoli, Italy Clinical Neurophysiology, Department of Endocrinological and Metabolic Sciences, University of Genoa, Genoa, Italy (literal)

Titolo

Identification by [99mTc]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinsons disease (literal)

Abstract

Abstract Progressive supranuclear palsy (PSP) is an akinetic-rigid syndrome that could be difficult to differentiate from Parkinsons disease (PD), particularly at an early stage. [99mTc]ECD SPET could be a widely available tool to help the differential diagnosis. Purpose. We used voxel-based analysis and Computerised Brain Atlas (CBA) based Principal Component Analysis (PCA) of [99mTc]ECD SPET data to test whether: 1) specific patterns of rCBF abnormalities could differentiate PSP from Controls and PD; 2) networks of dysfunctional brain regions could be found in PSP vs. Controls and PD. Methods. Nine PD, 16 PSP patients and 10 Controls were studied with [99mTc]ECD SPET using a brain-dedicated device (Ceraspect). Voxel-based analysis was performed with Statistical Parametric Mapping (SPM2). PCA was applied to VOI data after spatial normalisation to CBA. Results. The voxel-based analysis showed hypoperfusion of the anterior cingulate and medial frontal cortex in PSP compared with Controls and PD. In PSP patients the rCBF impairment extended to pre-supplementary motor area and prefrontal cortex, areas involved in executive function and motor networks. Compared with PSP, PD patients showed a mild rCBF decrease in associative visual areas which could relate to the known impairment of visuospatial function. The PCA identified 3 principal components differentiating PSP patients from Controls and/or PD patients that included groups of cortical and subcortical brain regions with relatively decreased (anterior and posterior cingulate cortex, prefrontal cortex, and caudate) or increased (parietal cortex) rCBF, representing distinct functional networks in PSP. Conclusions. Anterior cingulate hypoperfusion seems to be an early distinct brain abnormality in PSP as compared with PD. (literal)

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Autore CNR