DNA repair enzymes and cytotoxic effects of temozolomide: comparative studies between tumor cells and normal cells of the immune system. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• DNA repair enzymes and cytotoxic effects of temozolomide: comparative studies between tumor cells and normal cells of the immune system. (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• 1)PAGANI E, 1) PEPPONI R, 2)FUGGETTA MP, 3)PRETE SP, 3)TURRIZIANI M, 3)BONMASSAR L, 1)LACAL PM, 1)FALCINELLI S, 1)PASSARELLI F 4) GUADAGNI F, 2) ALVINO E, 1)D'ATRI S. (2003)
  DNA repair enzymes and cytotoxic effects of temozolomide: comparative studies between tumor cells and normal cells of the immune system.
  in Journal of chemotherapy (Testo stamp.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• 1)PAGANI E, 1) PEPPONI R, 2)FUGGETTA MP, 3)PRETE SP, 3)TURRIZIANI M, 3)BONMASSAR L, 1)LACAL PM, 1)FALCINELLI S, 1)PASSARELLI F 4) GUADAGNI F, 2) ALVINO E, 1)D'ATRI S. (literal)

Pagina inizio

• 173 (literal)

Pagina fine

• 183 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact factor = 1.088 Citations = 7 Web of Knoledge (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 15(2) (literal)

Rivista

• Journal of chemotherapy (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. IRCCS, IDI, I-00167 Rome, Italy 2. CNR, Inst Neurobiol & Mol Med, Rome, Italy 3. Univ Roma Tor Vergata, Dept Neurosci, Rome, Italy 4. Regina Elena Inst Canc Res, Rome, Italy (literal)

Titolo

• DNA repair enzymes and cytotoxic effects of temozolomide: comparative studies between tumor cells and normal cells of the immune system. (literal)

Abstract

• O6-alkylguanine-DNA alkyltransferase (OGAT) and the mismatch repair system (MRS) play a crucial role in the susceptibility of tumor cells to the cytotoxic effects of agents that generate O6-methylguanine in DNA, including the triazene compound temozolomide (TMZ). Studies performed with peripheral blood mononuclear cells (MNC) showed that TMZ was scarcely active on lymphocyte functions not dependent on cell proliferation (e.g. Nractivity and cytokine-mediated induction of CD1b molecule in adherent MNC). In contrast, TMZ depressed proliferation and lymphokine activated killer (LAK) cell generation in response to IL-2. In this case, a reasonably good inverse relationship was found between OGAT levels of MNC and their susceptibility to TMZ. This study also analyzed the ratio of the toxic effect of TMZ on MNC and on tumor cells (i.e.\"Tumor-Immune Function Toxicity Index\", TIFTI). A particularly favorable TIFTI can be obtained when OGAT levels are extremely high in MNC and markedly low in tumor cells. This holds true for MRS-proficient neoplastic cells, but not for MRS-deficient tumors. In conclusion, strategies aimed at modulating OGAT and MRS may improve the clinical response to TMZ. However, the use of OGAT inhibitors to potentiate the antitumor activity of TMZ might result in a concomitant increase of the immunosuppressive effects of the drug, thus reducing the relative TIFTI. (literal)

Prodotto di

• Target Molecolari, Modelli preclinici e Immunoterapia (ME.P03.006.001) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• MARIA PIA FUGGETTA (Unità di personale interno)
• ESTER ALVINO (Unità di personale interno)

Incoming links:

Autore CNR di

• MARIA PIA FUGGETTA (Unità di personale interno)
• ESTER ALVINO (Unità di personale interno)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Target Molecolari, Modelli preclinici e Immunoterapia (ME.P03.006.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of chemotherapy (Rivista)