Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• S. SANTI, S. CAPPELLO, M. RICCIO, M. BERGAMI, G AICARDI, U. SCHENK, M. MATTEOLI, M. CANOSSA, (2006)
  Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance.
  in EMBO journal (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• S. SANTI, S. CAPPELLO, M. RICCIO, M. BERGAMI, G AICARDI, U. SCHENK, M. MATTEOLI, M. CANOSSA, (literal)

Pagina inizio

• 4372 (literal)

Pagina fine

• 4380 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 25 (literal)

Rivista

• EMBO journal (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Univ Bologna, Dept Pharmacol, I-40126 Bologna, Italy 2. CNR, ITOI, ISMN, I-40126 Bologna, Italy 3. CNR, Dept Human & Gen Physiol, I-40126 Bologna, Italy 4. Univ Bologna, L Galvani Inter Dept Ctr, Bologna, Italy 5. Univ Milan, CNR IN, Dept Pharmacol, Milan, Italy (literal)

Titolo

• Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance. (literal)

Abstract

• Regulation of brain-derived neurotrophic factor (BDNF) secretion plays a critical role in long-term potentiation (LTP). It is generally thought that the supply for this secretion is newly synthesized BDNF targeted to the synapse. Here we provide evidence that hippocampal neurons additionally recycle BDNF for activity-dependent secretion. Exogenously applied BDNF is internalized by cultured neurons and rapidly becomes available for activity-dependent secretion, which is controlled by the same mechanisms that regulate the secretion of newly synthesized BDNF. Moreover, BDNF recycling replaced the new synthesis pathway in mediating the maintenance of LTP in hippocampal slices: the late phase LTP, which is abolished by protein synthesis inhibition, was rescued in slices preincubated with BDNF. Thus, endocytosed BDNF is fed back to the activity-dependent releasable pool required for LTP maintenance. (literal)

Prodotto di

• Farmacologia Cellulare e Molecolare delle Cellule Nervose (ME.P02.007.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)
• Imaging ottico in modelli bio e nanotecnologici (PM.P04.007.002) (Modulo)
• Basi molecolari e diagnostica delle neurodegenerazioni (ME.P02.017.001) (Modulo)

Autore CNR

• MICHELA MATTEOLI (Persona)
• SPARTACO SANTI (Persona)

Incoming links:

Autore CNR di

• SPARTACO SANTI (Persona)
• MICHELA MATTEOLI (Persona)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Farmacologia Cellulare e Molecolare delle Cellule Nervose (ME.P02.007.001) (Modulo)
• Basi molecolari e diagnostica delle neurodegenerazioni (ME.P02.017.001) (Modulo)
• Imaging ottico in modelli bio e nanotecnologici (PM.P04.007.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• EMBO journal (Rivista)