Hydrodynamic correlations in the translocation of a biopolymer through a nanopore: Theory and multiscale simulations (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Hydrodynamic correlations in the translocation of a biopolymer through a nanopore: Theory and multiscale simulations (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Fyta, M; Melchionna, S; Succi, S; Kaxiras, E (2008)
  Hydrodynamic correlations in the translocation of a biopolymer through a nanopore: Theory and multiscale simulations
  
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Fyta, M; Melchionna, S; Succi, S; Kaxiras, E (literal)

Pagina inizio

• 036704 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 78 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• \"[Fyta, Maria; Kaxiras, Efthimios] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA; [Melchionna, Simone; Kaxiras, Efthimios] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA; [Succi, Sauro] Harvard Univ, Initiat Innovat Comp, Cambridge, MA 02138 USA; [Melchionna, Simone] Univ Roma La Sapienza, Dept Phys, INFM SOFT, I-00185 Rome, Italy; [Succi, Sauro] CNR, Ist Applicaz Calcolo, I-00161 Rome, Italy (literal)

Titolo

• Hydrodynamic correlations in the translocation of a biopolymer through a nanopore: Theory and multiscale simulations (literal)

Abstract

• We investigate the process of biopolymer translocation through a narrow pore using a multiscale approach which explicitly accounts for the hydrodynamic interactions of the molecule with the surrounding solvent. The simulations confirm that the coupling of the correlated molecular motion to hydrodynamics results in significant acceleration of the translocation process. Based on these results, we construct a phenomenological model which incorporates the statistical and dynamical features of the translocation process and predicts a power-law dependence of the translocation time on the polymer length with an exponent alpha approximate to 1.2. The actual value of the exponent from the simulations is alpha=1.28 +/- 0.01, which is in excellent agreement with experimental measurements of DNA translocation through a nanopore, and is not sensitive to the choice of parameters in the simulation. The mechanism behind the emergence of such a robust exponent is related to the interplay between the longitudinal and transversal dynamics of both translocated and untranslocated segments. The connection to the macroscopic picture involves separating the contributions from the blob shrinking and shifting processes, which are both essential to the translocation dynamics. (literal)

Prodotto di

• Dinamica dei sistemi complessi fluidodinamici e biologici (MD.P02.002.001) (Modulo)
• Materia soffice: Self Assembly, Clustering, Arresto Strutturale (MD.P02.015.001) (Modulo)
• Istituto per le applicazioni del calcolo \"Mauro Picone\" (IAC) (Istituto)

Autore CNR

• SIMONE MELCHIONNA (Persona)
• SAURO SUCCI (Persona)

Insieme di parole chiave

• Parole chiave di "Hydrodynamic correlations in the translocation of a biopolymer through a nanopore: Theory and multiscale simulations" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• SIMONE MELCHIONNA (Persona)
• SAURO SUCCI (Persona)

Prodotto

• Istituto per le applicazioni del calcolo \"Mauro Picone\" (IAC) (Istituto)
• Dinamica dei sistemi complessi fluidodinamici e biologici (MD.P02.002.001) (Modulo)
• Materia soffice: Self Assembly, Clustering, Arresto Strutturale (MD.P02.015.001) (Modulo)

Insieme di parole chiave di

• Parole chiave di "Hydrodynamic correlations in the translocation of a biopolymer through a nanopore: Theory and multiscale simulations" (Insieme di parole chiave)