Induction of human NK cell-mediated cytotoxicity by CD40 triggering on antigen presenting cells. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Induction of human NK cell-mediated cytotoxicity by CD40 triggering on antigen presenting cells. (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Sartorius R., D'Apice L., Barba P., Guardiola J., Santoni A., Velotti F., De Berardinis P. (2003)
  Induction of human NK cell-mediated cytotoxicity by CD40 triggering on antigen presenting cells.
  in Cellular immunology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sartorius R., D'Apice L., Barba P., Guardiola J., Santoni A., Velotti F., De Berardinis P. (literal)

Pagina inizio

• 81 (literal)

Pagina fine

• 88 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 221 (literal)

Rivista

• Cellular immunology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IBP CNR, Italy; IGB CNR, Italy; (literal)

Titolo

• Induction of human NK cell-mediated cytotoxicity by CD40 triggering on antigen presenting cells. (literal)

Abstract

• Engagement of CD40 on antigen presenting cells (APC) is central to the initiation of cell-mediated immune response. Here, we investigated the ability of CD40 ligation on APC to induce NK cell-mediated cytotoxicity in the human system and the mechanism(s) underlying this process. We showed that APC (consisting in adherent peripheral blood mononuclear cells) (PBMC), pre-stimulated with anti-CD40 monoclonal antibodies and co-cultured with autologous non-adherent PBMC for 5-9 days, induced CD3-/CD56+ NK cell-mediated cytotoxicity as well as CD3+/CD56+ T cell-mediated unrestricted cytotoxic activity. The generation of NK cell-mediated cytotoxicity was independent on cell-to-cell contact between CD40-triggered APC and NK cells. Moreover, we found that IL-12 did not play a role in NK cells induction by anti-CD40 priming, while IL-2 and IL-15 did play a role. Our results provide an insight into the mechanism by which NK cells are activated in peripheral blood and useful information for therapeutic application of anti-CD40 antibodies. (literal)

Prodotto di

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Institute of protein biochemistry (IBP) (Istituto)

Autore CNR

• ROSSELLA SARTORIUS (Unità di personale interno)
• JOHN GUARDIOLA (Persona)
• PASQUALE BARBA (Persona)
• LUCIANA D'APICE (Unità di personale esterno)
• PIERGIUSEPPE DE BERARDINIS (Unità di personale interno)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Institute of protein biochemistry (IBP) (Istituto)

Autore CNR di

• PIERGIUSEPPE DE BERARDINIS (Unità di personale interno)
• LUCIANA D'APICE (Unità di personale esterno)
• JOHN GUARDIOLA (Persona)
• ROSSELLA SARTORIUS (Unità di personale interno)
• PASQUALE BARBA (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cellular immunology (Rivista)