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A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation (Articolo in rivista)
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- A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1038/sj.bjp.0705274 (literal)
- Alternative label
Frosini, Maria; Sesti, Casilde; Saponara, Simona; Ricci, Lorenzo; Valoti, Massimo; , Palmi, Mitri; Machetti, Fabrizio; Sgaragli, Giampietro (2003)
A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation
in British journal of pharmacology; Nature Publishing Group, London (Regno Unito)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Frosini, Maria; Sesti, Casilde; Saponara, Simona; Ricci, Lorenzo; Valoti, Massimo; , Palmi, Mitri; Machetti, Fabrizio; Sgaragli, Giampietro (literal)
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- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573873/ (literal)
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- Istituto di chimica dei composti organometallici del CNR
Dipartimento di chimica Organica 'Ugo Schiff' dell'Università di Firenze
Department of Pharmacology of Cornell University, New York, (United States)
Istituto di Scienze Farmacologiche dell' Università di Siena (literal)
- Titolo
- A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation (literal)
- Abstract
- 1 Taurine and GABA are recognized as endogenous cryogens. In a previous study, some structural
analogues of taurine, namely 6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide (TAG),
2-aminoethylarsonic (AEA), 2-hydroxyethanesulfonic (ISE) and (7)cis-2-aminocyclohexane sulfonic
acids (CAHS) have been shown to displace [3H]taurine binding from rabbit brain synaptic membrane
preparations, without interacting either with GABA-ergic systems, nor with taurine uptake
mechanism, thus behaving like direct taurinergic agents.
2 To answer the question whether the role of taurine as an endogenous cryogen depends on the
activation of GABA receptors or that of specific taurine receptor(s), taurine or the above structural
analogues were injected intracerebroventricularly in conscious, restrained rabbits singularly or in
combination and their effects on rectal (RT)- and ear skin temperature and gross motor behavior
(GMB) were monitored.
3 Taurine (1.210 4.8_10mol) induced a dose-related hypothermia, vasodilation at ear
vascular bed and inhibition of GMB. CAHS, at the highest dose tested (4.8_10 mol) induced a
taurine-like effect either on RT or GMB. On the contrary ISE, injected at the same doses of taurine,
induced a dose-related hyperthermia, vasoconstriction and excitation of GMB. AEA and TAG caused
a dose-related hyperthermia, but at doses higher than 1.2_10_7 mol caused death within 24 h after
treatment.
4 CAHS (4.810_ mol) antagonized the hyperthermic effect induced by TAG (1.2_10mol),
AEA (1.2_10_ mol) or ISE (4.8_10_mol).
5 In conclusion, these findings may indicate the existence of a recognition site specific for taurine,
responsible for its effects on thermoregulation. (literal)
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