http://www.cnr.it/ontology/cnr/individuo/prodotto/ID16307
Diterpenes from the Hainan Soft Coral Lobophytum cristatum Tixier-Durivault (Articolo in rivista)
- Type
- Label
- Diterpenes from the Hainan Soft Coral Lobophytum cristatum Tixier-Durivault (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1021/np2003325 (literal)
- Alternative label
Li, Liang; Sheng, Li; Wang, Chang-Yun; Zhou, Yu-Bo; Huang, Hui; Li, Xiu-Bao; Li, Jia; Mollo, Ernesto; Gavagnin, Margherita; Guo, Yue-Wei (2011)
Diterpenes from the Hainan Soft Coral Lobophytum cristatum Tixier-Durivault
in Journal of natural products (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Li, Liang; Sheng, Li; Wang, Chang-Yun; Zhou, Yu-Bo; Huang, Hui; Li, Xiu-Bao; Li, Jia; Mollo, Ernesto; Gavagnin, Margherita; Guo, Yue-Wei (literal)
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- Pagina fine
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Ocean University of China; Chinese Academy of Sciences; Chinese Academy of Sciences; Consiglio Nazionale delle Ricerche (CNR) (literal)
- Titolo
- Diterpenes from the Hainan Soft Coral Lobophytum cristatum Tixier-Durivault (literal)
- Abstract
- Two new prenylgermacrane-type diterpenoids, lobophytumins A and B (1 and 2), two new prenyleudesmane-type diterpenoids, lobophytumins C and D (3 and 4), and two new spatane-type diterpenoids, lobophytumins E and F (5 and 6), were isolated from the Hainan soft coral Lobophytum crista turn Tixier-Durivault. Their structures, including relative configuration, were elucidated by detailed analysis of spectroscopic data and by comparison with related known compounds. In addition, the absolute configuration of lobophytumin C (3) was tentatively assigned by comparing its specific rotation with that of the closely related model compound (-)-beta-selinene (8). On the basis of biogenetic considerations, the absolute configurations of lobophytumins A, B, and D F were also tentatively suggested. This is the first report of spatane-type diterpenoids from a soft coral source. The present work supports Faulkner's proposal of prenylgermacrene as the precursor of many diterpenes. In a bioassay, lobophytumins C and D (3 and 4) showed weak in vitro cytotoxicities against the tumor cell lines A-549 and HCT-116. (literal)
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- Autore CNR
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