http://www.cnr.it/ontology/cnr/individuo/prodotto/ID16199
Impact of histidine residue on chelating ability of 2'-deoxyriboadenosine (Articolo in rivista)
- Type
- Label
- Impact of histidine residue on chelating ability of 2'-deoxyriboadenosine (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.jinorgbio.2011.05.016 (literal)
- Alternative label
E. Lodyga-Chruscinska, S. Oldziej, E. Sochacka, K. Korzycka, L. Chruscinski, G. Micera, D. Sanna, M. Turek, J. Pawlak (2011)
Impact of histidine residue on chelating ability of 2'-deoxyriboadenosine
in Journal of inorganic biochemistry
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- E. Lodyga-Chruscinska, S. Oldziej, E. Sochacka, K. Korzycka, L. Chruscinski, G. Micera, D. Sanna, M. Turek, J. Pawlak (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.sciencedirect.com/science/article/pii/S0162013411001310 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Institute of General Food Chemistry, Technical University of Lódz, ul. Stefanowskiego 4/10, 90-924 Lódz, Poland
Laboratory of Biopolymer Structure, Intercollegiate Faculty of Biotechnology, University of Gdansk Medical University of Gdansk, Kladki 24, 80-822 Gdansk, Poland
Institute of Organic Chemistry, Technical University of Lódz, ul. Zeromskiego 176, 90-924 Lódz, Poland
Faculty of Process and Environmental Engineering, Technical University of Lódz ul. Wólczanska 213, 90-924 Lódz, Poland
Department of Chemistry, University of Sassari, via Vienna 2, I-07100 Sassari, Italy
Istituto C.N.R. Chim. Biomolecolare, Trav. La Crucca 3, reg. Baldinca, 07040 Sassari, Italy (literal)
- Titolo
- Impact of histidine residue on chelating ability of 2'-deoxyriboadenosine (literal)
- Abstract
- Copper(II) complexes with a new chelator-type nucleoside-histidine modified 2?-deoxyriboadenosine (N-[(9-?-D-2'-deoxyribofuranosylpurin-6-yl)-carbamoyl]histidine) were studied by potentiometric and spectroscopic (UV-visible, CD, EPR) techniques, in conjunction with computer modeling optimization. The ligand can act as bidentate or tridentate depending on pH range. In acidic pH a very stable dimeric complex Cu2L2 predominates with coordination spheres of both metal ions composed of oxygen atoms from carboxylic groups, one oxygen atom from ureido group and two nitrogen atoms derived from purine base and histidine ring. Above pH 5, deprotonation of carbamoyl nitrogens leads to the formation of CuL2, Cu2L2H- 1 and Cu2L2H- 2 species. The CuL2H- 1 and CuL2H- 2 complexes with three or four nitrogens in Cu(II) coordination sphere have been detected in alkaline medium.
Our findings suggest that N-[(9-?-D-2'-deoxyribofuranosylpurin-6-yl)-carbamoyl]histidine chelates copper(II) ions very efficiently. The resulting complex might be used as an alternative base-pairing mode in which hydrogen-bonded base pairs present in natural DNA are replaced by metal-mediated ones. (literal)
- Prodotto di
- Autore CNR
Incoming links:
- Autore CNR di
- Prodotto
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi