http://www.cnr.it/ontology/cnr/individuo/prodotto/ID16072
Targeting alphaVbeta3 Integrin: Design and Applications of Mono- and Multifunctional RGD-Based Peptides and Semipeptides (Articolo in rivista)
- Type
- Label
- Targeting alphaVbeta3 Integrin: Design and Applications of Mono- and Multifunctional RGD-Based Peptides and Semipeptides (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Auzzas L.; Zanardi F.; Battistini L.; Burreddu P.; Carta P.; Rassu G.; Curti C.; Casiraghi G. (literal)
- Pagina inizio
- Pagina fine
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- http://www.benthamdirect.org/pages/b_viewarticle.php (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- Scopu (literal)
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto di Chimica Biomolecolare del CNR, Traversa La Crucca 3, Li Punti, Sassari I-07100, Italy; Dipartimento Farmaceutico, Università degli Studi di Parma, Viale G. P. Usberti 27A, Parma I-43100, Italy (literal)
- Titolo
- Targeting alphaVbeta3 Integrin: Design and Applications of Mono- and Multifunctional RGD-Based Peptides and Semipeptides (literal)
- Abstract
- The outstanding physio-pathological role played by integrin receptors in living subjects motivates the enormous
interest shown by scientists worldwide for this topic. More than twenty years of research has spanned across the structural
and functional elucidation of these proteins and over their antagonism-based biomedical applications. The proof-ofconcept
stage, aimed at identifying potent inhibitors, covered a decade of studies, and paved the way for a more advanced
era of research where these antagonist molecules were thrown into the deep end of applicative studies. This review intends
to summarize the major efforts conducted thus far and focuses on the design, synthesis and biomedical applications of cyclic
RGD-containing alpha-v beta-3 integrin antagonists, in both their small and macromolecular formats. In particular, Chapters 1
and 2 offer a comprehensive outlook on the rational basis for the design of integrin inhibitors, Chapter 3 chronicles the
biological and medical applications of monofunctional RGD integrin ligands both in their monomeric and multimeric asset,
and Chapter 4 illustrates the potential of RGD-based multifunctional systems in molecular medicine. (literal)
- Prodotto di
- Autore CNR
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