Complex formation processes of terminally protected peptides containing two or three histidyl residues. Characterization of the mixed metal complexes of peptides. (Articolo in rivista)

Type
Label
  • Complex formation processes of terminally protected peptides containing two or three histidyl residues. Characterization of the mixed metal complexes of peptides. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1039/B808323A (literal)
Alternative label
  • S. Rajkovic, C. Kállay, R. Serényi, G. Malandrinos, N. Hadjiliadis, D. Sanna, I. Sóvágó (2008)
    Complex formation processes of terminally protected peptides containing two or three histidyl residues. Characterization of the mixed metal complexes of peptides.
    in Dalton transactions (2003. Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • S. Rajkovic, C. Kállay, R. Serényi, G. Malandrinos, N. Hadjiliadis, D. Sanna, I. Sóvágó (literal)
Pagina inizio
  • 5059 (literal)
Pagina fine
  • 5071 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://pubs.rsc.org/en/Content/ArticleLanding/2008/DT/b808323a (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovi?a 12, P.O. Box 60, 34000 Kragujevac, Serbia Department of Inorganic and Analytical Chemistry, University of Debrecen, H-4010 Debrecen, Hungary University of Ioannina, Department of Chemistry, Laboratory of Inorganic and General Chemistry, Ioannina 451 10, Greece Istituto CNR di Chimica Biomolecolare, trav. La Crucca 3, I-07040 Li Punti, Italy (literal)
Titolo
  • Complex formation processes of terminally protected peptides containing two or three histidyl residues. Characterization of the mixed metal complexes of peptides. (literal)
Abstract
  • Copper(II), nickel(II) and zinc(II) complexes of the peptides Ac-HVVH-NH2 and Ac-HAAHVVH-NH2 have been studied by potentiometric, UV-vis, CD, EPR and NMR spectroscopic measurements. Both tetra and heptapeptides can form relatively stable macrochelates with copper(II), nickel(II) and zinc(II) ions, in which the ligands are coordinated via the side-chain imidazole functions. Formation of the macrochelates slightly suppresses, but cannot prevent the copper(II) and nickel(II) ion promoted deprotonation and coordination of the amide functionalities. The overall stoichiometry of the major species is [MH-3L]- with a 4N (= N-,N-,N-,Nim) coordination mode. In the case of Ac-HAAHVVH-NH2, coordination isomers of this species can exist with a preference for copper(II) or nickel(II) binding at the internal histidyl residue. In the copper(II)-Ac-HAAHVVH-NH2 system, the presence of the two anchoring sites results in the formation of dinuclear complexes. The existence of these species requires the involvement of amide functions in metal binding. Both equilibrium and spectroscopic data support the fact that the copper(II) ions of the dinuclear species are independent from each other providing a good chance for the formation of various mixed metal complexes. It was found that zinc(II) is not able to significantly alter the copper(II) binding of the heptapeptide, but it can occupy the uncoordinated histidyl sites. The formation of the copper(II)-nickel(II) mixed species was obtained in alkaline solutions and CD spectra suggest the statistical distribution of the two metal ions among the histidyl residues. The binding of HAAHVVH to palladium(II) is exclusive below pH 8 and the mixed metal species of palladium(II) and copper(II) ions are formed only in slightly basic solutions. (literal)
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