Molecular alterations at chromosome 9p21 in melanocytic nevi and melanoma. (Articolo in rivista)

Type
Label
  • Molecular alterations at chromosome 9p21 in melanocytic nevi and melanoma. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1111/j.1365-2133.2007.08310.x (literal)
Alternative label
  • Sini MC; Manca A; Cossu A; Budroni M; Botti G; Ascierto PA; Cremona F; Muggiano A; D'Atri S; Casula M; Baldinu P; Palomba G; Lissia A; Tanda F; Palmieri G. (2008)
    Molecular alterations at chromosome 9p21 in melanocytic nevi and melanoma.
    in British journal of dermatology (1951. Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Sini MC; Manca A; Cossu A; Budroni M; Botti G; Ascierto PA; Cremona F; Muggiano A; D'Atri S; Casula M; Baldinu P; Palomba G; Lissia A; Tanda F; Palmieri G. (literal)
Pagina inizio
  • 243 (literal)
Pagina fine
  • 250 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 158 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Li Punti-Sassari; Istituto di Anatomia Patologica, Università degli Studi, Sassari; Centro di Osservazione Epidemiologica Multizonale, Azienda USL1, Sassari; Istituto Nazionale Tumori \"Fondazione G. Pascale\", Napoli; Associazione House Hospital Onlus, Napoli; Divisione di Oncologia Medica 1, Ospedale Oncologico Businco, Cagliari; Istituto Dermopatico dell'Immacolata (IDI), Roma; Italy. (literal)
Titolo
  • Molecular alterations at chromosome 9p21 in melanocytic nevi and melanoma. (literal)
Abstract
  • Background The chromosome 9p21 and its CDKN locus, with the p16 tumour suppressor gene (CDKN2A), are recognized as the genomic regions involved in the pathogenesis of melanoma. Objectives To elucidate further the role of such regions during the different phases of melanocytic tumorigenesis. Methods Tissue sections from naevi, primary and metastatic melanomas were investigated by fluorescence in situ hybridization for allelic loss at the 9p21 chromosome and by immunochemistry for p16CDKN2A expression. Results Dysplastic naevi and primary or secondary melanomas were found to carry hemizygous deletions within the entire 9p21 region at similar frequencies (varying from 55% to 62%). Allelic deletion spanning the CDKN locus was observed at significantly increased rates moving from early (7%) to advanced (28%) primary melanomas and to secondary melanoma lesions (37%) (P = 0Æ018). Also, inactivation of the p16 gene (CDKN2A) was absent in naevi and present at steadily increasing rates moving from primary melanomas (7% early lesions to 17% advanced lesions) to melanoma metastases (62%) (P = 0Æ004). Conclusions Our findings indicate that, in a model of sequential accumulation of genetic alterations, 9p21 deletions may play a role in melanocytic transformation and tumour initiation whereas rearrangements at the CDKN locus, and p16 gene (CDKN2A) inactivation may contribute to tumour progression (literal)
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