Antioxidant properties of phenols. (Articolo in rivista)

Type
Label
  • Antioxidant properties of phenols. (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1211/jpp.59.12.0010 (literal)
Alternative label
  • Foti Mario C. (2007)
    Antioxidant properties of phenols.
    in Journal of pharmacy and pharmacology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Foti Mario C. (literal)
Pagina inizio
  • 1673 (literal)
Pagina fine
  • 1685 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Selected and revised paper Conference: Workshop on Chemistry and Biology of Antioxidants, Location: Rome, ITALY, Date: JUL, 2007. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://onlinelibrary.wiley.com/doi/10.1211/jpp.59.12.0010/pdf (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 59 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 12 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Instituto di Chimica Biomolecolare del CNR, Via del Santuario, 110 Valverde (CT) 95028, Italy (literal)
Titolo
  • Antioxidant properties of phenols. (literal)
Abstract
  • The current understanding of the antioxidant properties of phenols (in homogeneous solutions) is reviewed, with particular emphasis on the role of the solvent. Phenols (ArOH) are known to reduce the rates of oxidation of organic matter by transferring a H atom (from their OH groups) to the chain-carrying ROOo radicals, a mechanism that most likely involves a concerted transfer of the hydrogen as a proton and of one electron between the two oxygen atoms, O-HoooOo (protoncoupled electron transfer mechanism). The antioxidant capabilities of phenols are strongly reduced by hydrogen-bond accepting solvents since the hydrogen-bonded molecules ArOHoooS are virtually unreactive toward ROOo radicals. The magnitude of these kinetic solvent effects is determined by the solute acidity a2H of ArOH (range 0 to 1) and solvent basicity b2H (range 0 to 1). Hydroxyl solvents (alcohols) have a double effect on ArOH. On the one hand, they act as hydrogen-bond accepting solvents and reduce the conventional rates of the ArOH + ROOo reaction. On the other hand, these solvents favour the ionization of ArOH into their phenoxide anions ArO-, which may react with ROOo very rapidly by electron transfer (sequential proton loss electron transfer mechanism). The overall effect is therefore determined by the ionization degree of ArOH. Other aspects of the kinetics and thermodynamics of ArOH + ROOo are also discussed. (literal)
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Autore CNR

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