Synthesis of water-solubile nucleotide-calixarene conjugates and preliminary investigation of their in vitro DNA replication inhibitory activity (Articolo in rivista)

Type
Label
  • Synthesis of water-solubile nucleotide-calixarene conjugates and preliminary investigation of their in vitro DNA replication inhibitory activity (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.tet.2007.06.123 (literal)
Alternative label
  • Consoli M.G.L.; Granata G.; Galante E.; Di Silvestro I.; Salafia L.; Geraci C. (2007)
    Synthesis of water-solubile nucleotide-calixarene conjugates and preliminary investigation of their in vitro DNA replication inhibitory activity
    in Tetrahedron (Oxf., Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Consoli M.G.L.; Granata G.; Galante E.; Di Silvestro I.; Salafia L.; Geraci C. (literal)
Pagina inizio
  • 10758 (literal)
Pagina fine
  • 10763 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 63 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 6 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 44 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Chimica Biomolecolare, C.N.R., Via del Santuario 110, I-95028 Valverde (CT), Italy Agroindustry Advanced Technologies, Centro Ricerche e Sviluppo, Blocco Palma I, Zona Industriale, I-95030 Catania, Italy (literal)
Titolo
  • Synthesis of water-solubile nucleotide-calixarene conjugates and preliminary investigation of their in vitro DNA replication inhibitory activity (literal)
Abstract
  • Calix[4]arenes bearing four thymine or adenine 20-deoxynucleotide moieties have been synthesized and characterized by NMR and ESI-MS analysis. Due to their amphiphilic nature, the conjugates (2a and 2b) obtained tend to self-assemble in aqueous medium by stacking interactions. Their good water solubility makes 2a and 2b promising candidates for bioorganic applications. A preliminary study has provided evidence of their inhibitory activity toward the replication of a Penicillium digitatum DNA fragment via PCR (polymerase chain reaction). (literal)
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