In vitro evaluation of quercetin-3-0-acyl esters as topical prodrugs (Articolo in rivista)

Type
Label
  • In vitro evaluation of quercetin-3-0-acyl esters as topical prodrugs (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.ijpharm.2006.12.003 (literal)
Alternative label
  • Montenegro L.; Carbone C.; Maniscalco C.; Lambusta D.; Nicolosi G.; Ventura C.A.; Puglisi G.. (2007)
    In vitro evaluation of quercetin-3-0-acyl esters as topical prodrugs
    in International journal of pharmaceutics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Montenegro L.; Carbone C.; Maniscalco C.; Lambusta D.; Nicolosi G.; Ventura C.A.; Puglisi G.. (literal)
Pagina inizio
  • 257 (literal)
Pagina fine
  • 262 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 336 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Pharmaceutical Sciences, University of Catania, V.le A.Doria 6, Catania I-95125, Italy Istituto di Chimica Biomolecolare, CNR, Sezione di Catania, Via del Santuario 110, I-95028 Valverde, Catania, Italy Pharmaco-Chemical Department, Faculty of Pharmacy, University of Messina, V.le Annunziata, Messina I-98168, Italy (literal)
Titolo
  • In vitro evaluation of quercetin-3-0-acyl esters as topical prodrugs (literal)
Abstract
  • Quercetin-3-O-acyl esters (I-VI) were synthesized and their usefulness as quercetin topical prodrugs was evaluated. Quercetin esters were assayed to determine their water stability and solubility, their susceptibility to undergoing enzymatic hydrolysis and their permeation through excised human skin. Quercetin ethyl (I) and hexyl (IV) esters proved poorly stable in aqueous media and they were not assayed further. Among the derivatives tested, quercetin propyl (II) and butyl (III) esters were more water-soluble than the parent drug. Esters II, III and V were readily hydrolyzed by human plasma and esters II and III penetrated excised human skin better than quercetin from aqueous saturated solutions. On the basis of the results obtained, esters II and III could be regarded as promising quercetin topical prodrugs. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it