http://www.cnr.it/ontology/cnr/individuo/prodotto/ID15542
omega-Alkoxy analogues of SAHA(vorinostat) as inhibitors of HDAC: a study of chain-lenght and stereochemical dependence. (Articolo in rivista)
- Type
- Label
- omega-Alkoxy analogues of SAHA(vorinostat) as inhibitors of HDAC: a study of chain-lenght and stereochemical dependence. (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.bmcl.2007.09.014 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Hanessian S.; Auzzas L.; Giannini G.; Marzi M.; Cabri W.; Barbarino M.; Vesci L.; Pisano C. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.sciencedirect.com/science/article/pii/S0960894X07010463 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Scopu (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Department of Chemistry, Université de Montréal, PO Box 6128, Station Centre-ville, Montréal, QC, Canada H3C 3J7; Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Traversa La Crucca 3, I-07040 Sassari, Italy; Sigma-Tau Research & Development, Via Pontina Km 30.400, I-00040 Pomezia, Roma, Italy (literal)
- Titolo
- omega-Alkoxy analogues of SAHA(vorinostat) as inhibitors of HDAC: a study of chain-lenght and stereochemical dependence. (literal)
- Abstract
- A series of omega-alkoxy ethers were prepared with variation of the length of the aliphatic chain of suberoylanilide hydroxamic acid (SAHA, vorinostat). Eight carbon long chain analogues showed the best activity, among which several substituted benzyl ether derivatives exhibited inhibitory activity on HDAC comparable to SAHA, and antiproliferative activity on three human cell lines (NB4, H460, and HCT-116) better than SAHA. However, no significant difference in antiproliferative activity was observed between two enantiomers bearing the benzyl ether moiety. (literal)
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