Chiral HPLC analysis of milnacipran and its FMOC-derivative on cellulose-based stationary phases (Articolo in rivista)

Type
Label
  • Chiral HPLC analysis of milnacipran and its FMOC-derivative on cellulose-based stationary phases (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/chir.20496 (literal)
Alternative label
  • Patti A; Pedotti S; Sanfilippo C. (2008)
    Chiral HPLC analysis of milnacipran and its FMOC-derivative on cellulose-based stationary phases
    in Chirality (N.Y., N.Y. Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Patti A; Pedotti S; Sanfilippo C. (literal)
Pagina inizio
  • 63 (literal)
Pagina fine
  • 68 (literal)
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  • 20 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 6 (literal)
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  • 2 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Chimica Biomolecolare del CNR, Via del Santuario 110, I-95028 Valverde CT, Italy (literal)
Titolo
  • Chiral HPLC analysis of milnacipran and its FMOC-derivative on cellulose-based stationary phases (literal)
Abstract
  • The HPLC enantioseparation of the last generation antidepressive drug milnacipran (±)-1 was investigated on different cellulose-based chiral stationary phases (CSPs). On carbamate-type columns, Chiralcel OD and OD-H (±)-1 could be separated with alpha value about 1.20 but the resolution was quite low because of the tailing of the peaks. Direct determination of (±)-1 with high selectivity and resolution was obtained on Chiralcel OJ in normal phase mode elution. Precolumn derivatization of milnacipran with Fmoc-Cl gave compound (±)-2 which was enantioseparated on all the investigated CSPs and allowed enhanced UV or fluorimetric detection. The Chiralpak IB, that could be considered the immobilized version of Chiralcel OD-H, was found completely ineffective in the chiral recognition of (±)-1 and moderately efficient in the separation of (±)-2. (literal)
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