CASC2a gene is downregulated in endometrial cancer. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• CASC2a gene is downregulated in endometrial cancer. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• Baldinu P; Cossu A; Manca A; Satta MP; Sini MC; Palomba G; Dessole S; Cherchi PL; Mara L; Tanda F; Palmieri G. (2007)
  CASC2a gene is downregulated in endometrial cancer.
  in Anticancer research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Baldinu P; Cossu A; Manca A; Satta MP; Sini MC; Palomba G; Dessole S; Cherchi PL; Mara L; Tanda F; Palmieri G. (literal)

Pagina inizio

• 235 (literal)

Pagina fine

• 243 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://ar.iiarjournals.org/content/27/1A/235.full.pdf+html (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 27 (literal)

Rivista

• Anticancer research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1A (literal)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto Chimica Biomolecolare-C.N.R., 07040 Li Punti-Sassari Servizio di Anatomia Patologica, Azienda U.S.L.1, 07100 Sassari Dipartimento di Ostetricia e Ginecologia, Università di Sassari, 07100 Sassari Istituto Zootecnico e Caseario per la Sardegna, Località Bonassai, 07040 Olmedo (SS), Italy (literal)

Titolo

• CASC2a gene is downregulated in endometrial cancer. (literal)

Abstract

• Background: Chromosome 10q25-q26 has been strongly correlated to endometrial tumorigenesis. A novel human gene, CASC2, has previously been identified at chromosome 10q26. One out of the three alternative transcripted forms, CASC2a, has been demonstrated to be mutated at a low frequency in endometrial cancer (EC). In this study, the role of the CASC2a gene in cancer has been further defined. Materials and Methods: Tumour and corresponding normal tissues were analysed for CASC2a mRNA expression by real-time RT-PCR and mutation status by PCR-based approaches. Results: A significantly decreased level of CASC2a transcripts was observed in 13/17 (76%) EC tissues, as well as in 6/9 (67%) colorectal cancers. Exogenous expression of CASC2a in undifferentiated AN3CA endometrial cancer cells inhibited cellular growth in anchorage-independent growth assays. Finally, infrequent CASC2a mutations were able to impair the gene function. Conclusion: Altogether, our findings strongly suggest that CASC2a may act as a tumour suppressor gene, with both epigenetic and genetic alterations concurring to gene inactivation. Down-regulation of CASC2a may provide a growth advantage in EC cells. (literal)

Prodotto di

• TERMINA 2010: Caratterizzazione genetico-molecolare della tumorigenesi (PM.P01.017.004) (Modulo)
• Istituto di chimica biomolecolare (ICB) (Istituto)

Autore CNR

• MARIA CRISTINA SINI (Persona)
• GIUSEPPE PALMIERI (Persona)
• PAOLA BALDINU (Unità di personale esterno)
• GRAZIA PALOMBA (Persona)
• MARIA PAOLA SATTA (Unità di personale esterno)
• ANTONELLA MANCA (Persona)

Insieme di parole chiave

• Keywords of "CASC2a gene is downregulated in endometrial cancer." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIUSEPPE PALMIERI (Persona)
• ANTONELLA MANCA (Persona)
• PAOLA BALDINU (Unità di personale esterno)
• GRAZIA PALOMBA (Persona)
• MARIA PAOLA SATTA (Unità di personale esterno)
• MARIA CRISTINA SINI (Persona)

Prodotto

• Istituto di chimica biomolecolare (ICB) (Istituto)
• TERMINA 2010: Caratterizzazione genetico-molecolare della tumorigenesi (PM.P01.017.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Anticancer research (Rivista)

Insieme di parole chiave di

• Keywords of "CASC2a gene is downregulated in endometrial cancer." (Insieme di parole chiave)