Exploring Alternative Zn-binding Groups in the Design of HDAC inhibitors: Squaric Acid, N-Hydroxyurea, and Oxazoline Analogues of SAHA (Articolo in rivista)

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  • Exploring Alternative Zn-binding Groups in the Design of HDAC inhibitors: Squaric Acid, N-Hydroxyurea, and Oxazoline Analogues of SAHA (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bmcl.2006.06.090 (literal)
Alternative label
  • Hanessian S.; Vinci V.; Auzzas L.; Marzi M.; Giannini G. (2006)
    Exploring Alternative Zn-binding Groups in the Design of HDAC inhibitors: Squaric Acid, N-Hydroxyurea, and Oxazoline Analogues of SAHA
    in Bioorganic and medicinal chemistry letters (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Hanessian S.; Vinci V.; Auzzas L.; Marzi M.; Giannini G. (literal)
Pagina inizio
  • 4784 (literal)
Pagina fine
  • 4787 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.sciencedirect.com/science/article/pii/S0960894X06007499 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 16 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 18 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Chemistry, Universit√© de Montreal, PO Box 6128, Station Centre-ville, Montreal, Quebec, Canada H3C 3J7; Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Traversa La Crucca 3, I-07040 Sassari, Italy; Department of Chemistry, Universit√© de Montreal, PO Box 6128, Station Centre-ville, Montreal, Quebec, Canada H3C 3J7; Sigma-Tau Research & Development, Via Pontina Km 30.400, 00040 Pomezia, Roma, Italy (literal)
Titolo
  • Exploring Alternative Zn-binding Groups in the Design of HDAC inhibitors: Squaric Acid, N-Hydroxyurea, and Oxazoline Analogues of SAHA (literal)
Abstract
  • Analogues of suberoylanilide hydroxamic acid (SAHA) were prepared by replacing the Zn-binding group with squaric acid, N-hydroxyurea, and 4-hydroxymethyl oxazoline units, also varying the length of the aliphatic chain. No inhibitory activity on HDAC was observed below 1.0 microM and no cytotoxic activity on different tumor cell lines was seen below 20.0 microM. (literal)
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