Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels (Articolo in rivista)

Type
Label
  • Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/sj.emboj.7600784 (literal)
Alternative label
  • Van der Stelt M; Trevisani M; Vellani V; De Petrocellis L; Schiano Moriello A; Campi B; McNaughton P; Geppetti P; Di Marzo V (2005)
    Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels
    in EMBO journal (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Van der Stelt M; Trevisani M; Vellani V; De Petrocellis L; Schiano Moriello A; Campi B; McNaughton P; Geppetti P; Di Marzo V (literal)
Pagina inizio
  • 3026 (literal)
Pagina fine
  • 3037 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Erratum: The EMBO Journal (2005) 24, 3517-3518. doi:10.1038/sj.emboj.7600839 Correction to: The EMBO Journal (2005) 24, 3026-3037. doi:10.1038/sj.emboj.7600784 Due to a typesetting error, Figure 2 was published incorrectly in print and online. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.nature.com/emboj/journal/v24/n17/full/7600784a.html (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 24 (literal)
Rivista
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  • 12 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 17 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli (NA), Italy Department of Experimental Medicine and Clinical Medicine, Pharmacology Unit, University of Ferrara, Ferrara, Italy Dipartimento di Scienze Biomediche, Universita' di Modena e Reggio Emilia, Modena, Italy Department of Pharmacology, University of Cambridge, Cambridge, UK Istitute of Cibernetica Eduardo Caianiello, Consiglio Nazionale delle Ricerche, Pozzuoli (NA), Italy (literal)
Titolo
  • Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels (literal)
Abstract
  • The endocannabinoid anandamide is able to interact with the transient receptor potential vanilloid 1 (TRPV1) channels at a molecular level. As yet, endogenously produced anandamide has not been shown to activate TRPV1, but this is of importance to understand the physiological function of this interaction. Here, we show that intracellular Ca2+ mobilization via the purinergic receptor agonist ATP, the muscarinic receptor agonist carbachol or the Ca(2+)-ATPase inhibitor thapsigargin leads to formation of anandamide, and subsequent TRPV1-dependent Ca2+ influx in transfected cells and sensory neurons of rat dorsal root ganglia (DRG). Anandamide metabolism and efflux from the cell tonically limit TRPV1-mediated Ca2+ entry. In DRG neurons, this mechanism was found to lead to TRPV1-mediated currents that were enhanced by selective blockade of anandamide cellular efflux. Thus, endogenous anandamide is formed on stimulation of metabotropic receptors coupled to the phospholipase C/inositol 1,4,5-triphosphate pathway and then signals to TRPV1 channels. This novel intracellular function of anandamide may precede its action at cannabinoid receptors, and might be relevant to its control over neurotransmitter release. (literal)
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