Acid-base properties and copper(II) complexes of dipeptides containing histidine and additional chelating bis(imidazol-2-yl) residues (Articolo in rivista)

Type
Label
  • Acid-base properties and copper(II) complexes of dipeptides containing histidine and additional chelating bis(imidazol-2-yl) residues (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.jinorgbio.2003.09.009 (literal)
Alternative label
  • Õsz K., Varnagy K., Suli-Vargha H., Csampany A., Sanna D., Micera G., I. Sovago (2004)
    Acid-base properties and copper(II) complexes of dipeptides containing histidine and additional chelating bis(imidazol-2-yl) residues
    in Journal of inorganic biochemistry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Õsz K., Varnagy K., Suli-Vargha H., Csampany A., Sanna D., Micera G., I. Sovago (literal)
Pagina inizio
  • 24 (literal)
Pagina fine
  • 32 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.sciencedirect.com/science/article/pii/S0162013403003829 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 98 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Inorganic and Analytical Chemistry, University of Debrecen, P.O. Box 21, Debrecen H-4010, Hungary Research Group of Peptide Chemistry, Hungarian Academy of Sciences, P.O. Box 32, H-1518 Budapest 112, Hungary Department of General and Inorganic Chemistry, Eötvös Loránd University, P.O. Box 32, H-1518 Budapest 112, Hungary Istituto C.N.R. di Chimica Biomolecolare, Sezione di Sassari, Trav. La Crucca 3 Reg. Baldinca, I-07040 Sassari, Italy Department of Chemistry, University of Sassari, Via Vienna 2, I-07100 Sassari, Italy (literal)
Titolo
  • Acid-base properties and copper(II) complexes of dipeptides containing histidine and additional chelating bis(imidazol-2-yl) residues (literal)
Abstract
  • Copper(II) complexes of dipeptides of histidine containing additional chelating bis(imidazol-2-yl) agent at the C-termini (PheHis-BIMA [N-phenylalanyl-histidyl-bis(imidazol-2-yl)methylamine] and HisPhe-BIMA [N-histidyl-phenylalanyl-bis(imidazol-2-yl)methylamine]) were studied by potentiometric, UV-Visible and Electron Paramagnetic Resonance (EPR) techniques. The imidazole nitrogen donor atoms of the bis(imidazol-2-yl)methyl group are described as the primary metal binding sites forming stable mono- and bis(ligand) complexes at acidic pH. The formation of a ligand-bridged dinuclear complex [Cu2L2]4+ is detected in equimolar solutions of copper(II) and HisPhe-BIMA. The coordination isomers of the dinuclear complex are described via the metal binding of the bis(imidazol-2-yl)methyl, amino-carbonyl and amino-imidazole(His) functions. In the case of the copper(II)-PheHis-BIMA system the [NH2, N-(amide), N(Im)] tridentate coordination of the ligand is favoured and results in the formation of di- and trinuclear complexes [Cu2H-1L]3+ and [Cu3H-2L2]4+ in equimolar solutions. The presence of these coordination modes shifts the formation of \"tripeptide-like\" ([NH2, N-, N-, N(Im)]-coordinated) [CuH-2L] complexes into alkaline pH range as compared to other dipeptide derivatives of bis(imidazol-2-yl) ligands. Although there are different types of imidazoles in these ligands, the deprotonation and coordination of the pyrrole-type N(1)H groups does not occur below pH 10. (literal)
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