Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis. (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/S1535-6108(04)00021-2 (literal)

Alternative label

• D'Angelo A.; Garzia L.; Andrè A.; Carotenuto P.; Aglio V.; Guardiola O.; Arrigoni G.; Cossu A.; Palmieri G.; Aravind L.; Zollo M. (2004)
  Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis.
  in Cancer cell (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• D'Angelo A.; Garzia L.; Andrè A.; Carotenuto P.; Aglio V.; Guardiola O.; Arrigoni G.; Cossu A.; Palmieri G.; Aravind L.; Zollo M. (literal)

Pagina inizio

• 137 (literal)

Pagina fine

• 149 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 5 (literal)

Rivista

• Cancer cell (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Telethon Institute of Genetics and Medicine, TIGEM, Via Pietro Castellino 111, 80131 Naples, Italy; Ospedale San Raffaele, Department of Anatomy and Pathology, HSR, Milan, Italy; Azienda A.S.L. n° 1 - Sassari, Department of Pathology - University of Sassari - Italy; Istituto di Chimica Biomolecolare - Sezione di Sassari, Consiglio Nazionale delle Ricerche Tramariglio, Alghero, Italy; National Institutes of Health (NIH), Computational Biology Branch, NCBI, NLM, Bethesda, MD 20894, USA. (literal)

Titolo

• Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis. (literal)

Abstract

• We identify a new enzymatic activity underlying metastasis in breast cancer and describe its susceptibility to therapeutic inhibition. We show that human prune (h-prune), a phosphoesterase DHH family appertaining protein, has a hitherto unrecognized cyclic nucleotide phosphodiesterase activity effectively suppressed by dipyridamole, a phosphodiesterase inhibitor. H-prune physically interacts with nm23-H1, a metastasis suppressor gene. The h-prune PDE activity, suppressed by dipyridamole and enhanced by the interaction with nm23-H1, stimulates cellular motility and metastasis processes. Out of 59 metastatic breast cancer cases analyzed, 22 (37%) were found to overexpress h-prune, evidence that this novel enzymatic activity is involved in promoting cancer metastasis. (literal)

Prodotto di

• Institute of biomolecular chemistry (ICB) (Istituto)
• TERMINA 2010: Caratterizzazione genetico-molecolare della tumorigenesi (PM.P01.017.004) (Modulo)

Autore CNR

• GIUSEPPE PALMIERI (Persona)

Incoming links:

Autore CNR di

• GIUSEPPE PALMIERI (Persona)

Prodotto

• Institute of biomolecular chemistry (ICB) (Istituto)
• TERMINA 2010: Caratterizzazione genetico-molecolare della tumorigenesi (PM.P01.017.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cancer cell (Rivista)