Interaction between the low molecular mass components of blood serum and the VO(IV)-DHP system (DHP = 1, 2-dimethyl-3-hydroxy-4(1H)-pyridinone) (Articolo in rivista)

Type
Label
  • Interaction between the low molecular mass components of blood serum and the VO(IV)-DHP system (DHP = 1, 2-dimethyl-3-hydroxy-4(1H)-pyridinone) (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1039/B200688J (literal)
Alternative label
  • Buglyò P., Kiss T., Kiss E., Sanna D., Garribba E., Micera G. (2002)
    Interaction between the low molecular mass components of blood serum and the VO(IV)-DHP system (DHP = 1, 2-dimethyl-3-hydroxy-4(1H)-pyridinone)
    in Journal of the Chemical Society. Dalton Transactions (2001)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Buglyò P., Kiss T., Kiss E., Sanna D., Garribba E., Micera G. (literal)
Pagina inizio
  • 2275 (literal)
Pagina fine
  • 2282 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://pubs.rsc.org/en/Content/ArticleLanding/2002/DT/b200688j (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Inorganic and Analytical Chemistry, University of Debrecen, P.O. Box 21, Hungary Department of Inorganic and Analytical Chemistry, University of Szeged, P.O. Box 440, Hungary Biocoordination Chemistry Research Group of the Hungarian Academy of Sciences, University of Szeged, P.O.Box 440, Hungary Instituto C.N.R. per l'Applicazione delle Technice Chimiche Avanzate ai Problemi Agrobiologici, Via Vienna 2, Italy Department of Chemistry, University of Sassari, Via Vienna 2, Italy (literal)
Titolo
  • Interaction between the low molecular mass components of blood serum and the VO(IV)-DHP system (DHP = 1, 2-dimethyl-3-hydroxy-4(1H)-pyridinone) (literal)
Abstract
  • In order to estimate the impact of the low molecular mass (l.m.m.) VO(IV) binders of blood serum on the potentially insulin-enhancing drug [VO(DHP) 2] [DHP = 1,2-dimethyl-3-hydroxy-4(1H)-pyridinone] , the speciation in the binary system VO(IV)-DHP and in the ternary systems VO(IV)-DHP-ligand B (B = oxalate, lactate, citrate or phosphate) was studied by pH-potentiometry. The binding modes of the complexes formed were determined by spectroscopic (electronic absorption and EPR) techniques. DHP was found to form stable mono and bis complexes via the coordination of (O,O) chelate(s). Through displacement of the oxo group of VO(IV), the tris complex is also formed, especially at high excess of ligand. The results in the ternary system demonstrate that, at physiological pH, none of the B ligands can compete with DHP; [VO(DHP)2] therefore seems to remain almost completely intact, even in the presence of citrate, the strongest competitor among these B ligands. These findings indicate that, for DHP, unlike maltol or picolinic acid, ternary complex formation and thus transformation reactions with the l.m.m. binders of biofluids, is almost negligible. From among the three carrier molecules, only DHP can efficiently compete with serum transferrin for binding of VO(IV). (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it