Extremely-low frequency magnetic field modulates differentiation and maturation of human and rat primary and multipotent stem cells. (Contributo in volume (capitolo o saggio))

Type
Label
  • Extremely-low frequency magnetic field modulates differentiation and maturation of human and rat primary and multipotent stem cells. (Contributo in volume (capitolo o saggio)) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Ledda M, De Carlo F, D’Emilia E, Giuliani L, Grimaldi S, and Lisi A. (2010)
    Extremely-low frequency magnetic field modulates differentiation and maturation of human and rat primary and multipotent stem cells.
    in , 2010
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Ledda M, De Carlo F, D’Emilia E, Giuliani L, Grimaldi S, and Lisi A. (literal)
Pagina inizio
  • 135 (literal)
Pagina fine
  • 147 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#volumeInCollana
  • 5 (literal)
Note
  • Scopus (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Translational Pharmacology, National Research Council, Rome, Italy; Institute of Translational Pharmacology . (literal)
Titolo
  • Extremely-low frequency magnetic field modulates differentiation and maturation of human and rat primary and multipotent stem cells. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#inCollana
  • European Journal of Oncology - Library vol. 5, pag.135-147 (literal)
Abstract
  • In the last 15 years, we reported numerous biological effects of extremely-low frequency electromagnetic fields (ELF-EMF) on different cells types. We showed morphological and cytoskeletal changes in keratinocyte cell lines exposed to a 50-Hz 2 mT ELF-EMF. Furthermore, we reported that very high magnetic field (MF) intensity promotes maturation and differentiation in newborn cerebellar granule cells, and a 50-Hz 2 mT ELF-EMF produced a sudden increase in the intracellular calcium level in rat anterior pituitaryderived AtT20 D16V cells followed by a reorganization of the cytoskeletal network via polymerization of actin and differentiation of protein expression. Recently, we showed that a combination of static and alternate EMFs, tuned to Ca2+ ion cyclotron energy resonance (Ca2+-ICR) was able to trigger human cardiac stem sell-specific differentiation. In the present review, we report a summary of the most relevant results that we have reached in the last 7 years, in particular, we focus the attention on the differentiation effect of ELF-EMF on 3 different types of primary cell culture: human oral keratinocytes (HOK), newborn rat cerebellar granule neurons (CGN), and human adult cardiac stem cells (CSC). (literal)
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