http://www.cnr.it/ontology/cnr/individuo/prodotto/ID14284
Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study. (Articolo in rivista)
- Type
- Label
- Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study. (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Alternative label
Tedeschi G, Dinacci D, Comerci M, Lavorgna L, Savettieri G, Quattrone A, Livrea P, Patti F, Morra VB, Servillo G, Orefice G, Paciello M, Prinster A, ..., Quarantelli M, Brunetti A, ..., Salvatore M, Bonavita V, Alfano B (2009)
Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study.
in Multiple sclerosis
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- Tedeschi G, Dinacci D, Comerci M, Lavorgna L, Savettieri G, Quattrone A, Livrea P, Patti F, Morra VB, Servillo G, Orefice G, Paciello M, Prinster A, ..., Quarantelli M, Brunetti A, ..., Salvatore M, Bonavita V, Alfano B (literal)
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- ISI Web of Science (WOS) (literal)
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- istituto di biostrutture e bioimmagini (literal)
- Titolo
- Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up study. (literal)
- Abstract
- Background To investigate in a large cohort of patients with multiple sclerosis (MS), lesion load
and atrophy evolution, and the relationship between clinical and magnetic resonance imaging
(MRI) correlates of disease progression.
Methods Two hundred and sixty-seven patients with MS were studied at baseline and two years later
using the same MRI protocol. Abnormal white matter fraction, normal appearing white matter fraction,
global white matter fraction, gray matter fraction and whole brain fraction, T2-hyperintense, and
T1-hypointense lesions were measured at both time points.
Results The majority of patients were clinically stable, whereas MRI-derived brain tissue fractions
were significantly different after 2 years. The correlation between MRI data at baseline and their variation
during the follow-up showed that lower basal gray matter atrophy was significantly related
with higher progression of gray matter atrophy during follow-up. The correlation between MRI parameters
and disease duration showed that gray matter atrophy rate decreased with increasing disease
duration, whereas the rate of white matter atrophy had a constant pattern. Lower basal gray matter
atrophy was associated with increased probability of developing gray matter atrophy at follow-up,
whereas gray matter atrophy progression over 2 years and new T2 lesion load were risk factors for
whole brain atrophy progression.
Conclusions In MS, brain atrophy occurs even after a relatively short period of time and in patients
with limited progression of disability. Short-term brain atrophy progression rates differ across tissue
compartments, as gray matter atrophy results more pronounced than white matter atrophy and
appears to be a early phenomenon in the MS-related disease progression. Multiple Sclerosis 2009;
15: 204-211. http://msj.sagepub.com (literal)
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