Multiple catalytically active thioredoxin folds: a winning strategy for many functions. (Articolo in rivista)

Type
Label
  • Multiple catalytically active thioredoxin folds: a winning strategy for many functions. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/s00018-010-0449-9 (literal)
Alternative label
  • Pedone E; Limauro D; D'Ambrosio K; De Simone G; Bartolucci S (2010)
    Multiple catalytically active thioredoxin folds: a winning strategy for many functions.
    in Cellular and molecular life sciences (Print. ed.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pedone E; Limauro D; D'Ambrosio K; De Simone G; Bartolucci S (literal)
Pagina inizio
  • 3797 (literal)
Pagina fine
  • 3814 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 67 (literal)
Rivista
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy Dipartimento di Biologia Strutturale e Funzionale, Università degli Studi di Napoli ''Federico II'', Complesso Universitario Monte S. Angelo, Via Cinthia, 80126 Naples, Italy (literal)
Titolo
  • Multiple catalytically active thioredoxin folds: a winning strategy for many functions. (literal)
Abstract
  • The Thioredoxin (Trx) fold is a versatile protein scaffold consisting of a four-stranded b-sheet surrounded by three a-helices. Various insertions are possible on this structural theme originating different proteins, which show a variety of functions and specificities. During evolution, the assembly of different Trx fold domains has been used many times to build new multi-domain proteins able to perform a large number of catalytic functions. To clarify the interaction mode of the different Trx domains within a multi-domain structure and how their combination can affect catalytic performances, in this review, we report on a structural and functional analysis of the most representative proteins containing more than one catalytically active Trx domain: the eukaryotic protein disulfide isomerases (PDIs), the thermophilic protein disulfide oxidoreductases (PDOs) and the hybrid peroxiredoxins (Prxs). (literal)
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