Recent advances in structural studies of the carbonic anhydrase family: the crystal structure of human CA IX and CA XIII. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Recent advances in structural studies of the carbonic anhydrase family: the crystal structure of human CA IX and CA XIII. (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.2174/138161210793429841 (literal)

Alternative label

• Supuran CT; Di Fiore A; Alterio V; Monti SM; De Simone G. (2010)
  Recent advances in structural studies of the carbonic anhydrase family: the crystal structure of human CA IX and CA XIII.
  in Current pharmaceutical design (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Supuran CT; Di Fiore A; Alterio V; Monti SM; De Simone G. (literal)

Pagina inizio

• 3246 (literal)

Pagina fine

• 3254 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 16 (literal)

Rivista

• Current pharmaceutical design (Rivista)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Università degli Studi di Pirenze, Polo Scientifico, Laboratorio di Chimica Ioinorganica Istituto di Biostrutture e Bioimmagini-CNR (literal)

Titolo

• Recent advances in structural studies of the carbonic anhydrase family: the crystal structure of human CA IX and CA XIII. (literal)

Abstract

• The carbonic anhydrase (CA) family has recently become an important target for the drug design of inhibitors with potential use as diagnostic and therapeutic tools. However, given the high degree of sequence and structure similarity among the different CA isoforms, no CA-directed drug developed so far has displayed selectivity for a specific isozyme. Since X-Ray crystallography is a very useful tool for the rational drug design of selective enzyme inhibitors, in recent years extensive research efforts have been devoted to the structural studies of all catalytically active α-CA isoforms, with the consequent resolution of the crystallographic structures of nearly all such enzyme isoforms. In this paper we review the progress that has recently been made in this field. In particular, we summarize the main structural features of hCA XIII and hCA IX, the most recently characterized human CA isoforms, and recapitulate how 3D structures of these enzymes, together with kinetic experiments, have been used either to deepen our knowledge on the structural features responsible of the catalytic properties of this protein family or to obtain important information for the rational drug design of inhibitors with better selectivity properties. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Determinazione della struttura tridimensionale di biomolecole complesse con tecniche spettroscopiche e cristallografiche (PM.P01.022.001) (Modulo)

Autore CNR

• SIMONA MARIA MONTI (Unità di personale interno)
• VINCENZO ALTERIO (Persona)
• GIUSEPPINA DE SIMONE (Unità di personale interno)
• ANNA DI FIORE (Persona)

Insieme di parole chiave

• Parole chiave di "Recent advances in structural studies of the carbonic anhydrase family: the crystal structure of human CA IX and CA XIII." (Insieme di parole chiave)

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Autore CNR di

• GIUSEPPINA DE SIMONE (Unità di personale interno)
• SIMONA MARIA MONTI (Unità di personale interno)
• VINCENZO ALTERIO (Persona)
• ANNA DI FIORE (Persona)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Determinazione della struttura tridimensionale di biomolecole complesse con tecniche spettroscopiche e cristallografiche (PM.P01.022.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Current pharmaceutical design (Rivista)

Insieme di parole chiave di

• Parole chiave di "Recent advances in structural studies of the carbonic anhydrase family: the crystal structure of human CA IX and CA XIII." (Insieme di parole chiave)