Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s00726-009-0361-5 (literal)

Alternative label

• Roviello GN; Di Gaetano S; Capasso D; Cesarani A; Bucci EM; Pedone C. (2010)
  Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity
  in Amino acids (Wien, Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Roviello GN; Di Gaetano S; Capasso D; Cesarani A; Bucci EM; Pedone C. (literal)

Pagina inizio

• 1489 (literal)

Pagina fine

• 1496 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 38 (literal)

Rivista

• Amino acids (Rivista)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• G. N. Roviello (&) ? S. D. Gaetano ? A. Cesarani ? E. M. Bucci Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, 80134 Naples, Italy e-mail: giroviel@unina.it D. Capasso ? C. Pedone Dipartimento delle Scienze Biologiche, Universita` di Napoli ''Federico II'', 80134 Naples, Italy (literal)

Titolo

• Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (literal)

Abstract

• In this work, we report the synthesis of an alternate nucleo-alpha,epsilon-peptide based on L-lysine moieties, an in vitro study of its biological activity, and spectroscopical binding studies between the novel nucleopeptide and Moloney murine leukemia virus reverse transcriptase as well as RNA. An alternate homothymine hexamer was synthesized by a straightforward solid phase route starting from commercial materials, purified by RP-HPLC and characterized by ESI-MS. The efficiency of the novel nucleo-alpha,epsilon-peptide in interfering with the reverse transcription of eukaryotic mRNA and the noteworthy enzymatic resistance demonstrated by specific assays are in favor of the employment of this nucleopeptide in novel biomedical strategies. (literal)

Prodotto di

• Sistemi sintetici riconoscibili da target biologici (PM.P01.003.001) (Modulo)
• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• GIOVANNI ROVIELLO (Unità di personale interno)
• SONIA DI GAETANO (Unità di personale interno)
• ENRICO BUCCI (Persona)

Insieme di parole chiave

• Keywords of "Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• SONIA DI GAETANO (Unità di personale interno)
• GIOVANNI ROVIELLO (Unità di personale interno)
• ENRICO BUCCI (Persona)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Sistemi sintetici riconoscibili da target biologici (PM.P01.003.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Amino acids (Rivista)

Insieme di parole chiave di

• Keywords of "Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity" (Insieme di parole chiave)