http://www.cnr.it/ontology/cnr/individuo/prodotto/ID14063
Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake (Articolo in rivista)
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- Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.cellsig.2009.01.022 (literal)
- Alternative label
Illario, Maddalena; Monaco, Sara; Cavallo, Anna Lina; Esposito, Iolanda; Formisano, Pietro; D'Andrea, Luca; Cipolletta, Ersilia; Trimarco, Bruno; Fenzi, Gianfranco; Rossi, Guido; Vitale, Mario (2009)
Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake
in Cellular signalling
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Illario, Maddalena; Monaco, Sara; Cavallo, Anna Lina; Esposito, Iolanda; Formisano, Pietro; D'Andrea, Luca; Cipolletta, Ersilia; Trimarco, Bruno; Fenzi, Gianfranco; Rossi, Guido; Vitale, Mario (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Illario, Maddalena; Univ Naples Federico 2, Dept Biol & Patol Cellulare & Mol, I-80131 Naples, Italy
Monaco, Sara; Univ Naples Federico 2, Dept Biol & Patol Cellulare & Mol, I-80131 Naples, Italy
Cavallo, Anna Lina; Univ Naples Federico 2, Dept Biol & Patol Cellulare & Mol, I-80131 Naples, Italy
Esposito, Iolanda; Univ Naples Federico 2, Dept Biol & Patol Cellulare & Mol, I-80131 Naples, Italy
Formisano, Pietro; Univ Naples Federico 2, Dept Biol & Patol Cellulare & Mol, I-80131 Naples, Italy
D'Andrea, Luca; CNR, Inst Biostruct & Bioimmagini, I-80131 Naples, Italy
Cipolletta, Ersilia; Univ Naples Federico 2, Dept Med Clin & Sci Cardiovasc & Immunol, I-80131 Naples, Italy
Trimarco, Bruno; Univ Naples Federico 2, Dept Med Clin & Sci Cardiovasc & Immunol, I-80131 Naples, Italy
Fenzi, Gianfranco; Univ Naples Federico 2, Dept Endocrinol & Oncol Mol & Clin, I-80131 Naples, Italy
Rossi, Guido; Univ Naples Federico 2, Dept Biol & Patol Cellulare & Mol, I-80131 Naples, Italy
Vitale, Mario, Univ Naples Federico 2, Dept Endocrinol & Oncol Mol & Clin, I-80131 Naples, Italy (literal)
- Titolo
- Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake (literal)
- Abstract
- Cellular growth and glucose uptake are regulated by multiple signals generated by the insulin receptor. The mechanisms of individual modulation of these signals remain somewhat elusive. We investigated the role of CaMKII in insulin signalling in a rat skeletal muscle cell line, demonstrating that CaMKII modulates the insulin action on DNA synthesis and the negative feedback that down regulates glucose uptake. Insulin stimulation generated partly independent signals leading to the rapid activation of Akt, Erk-1/2 and CaMKII Akt activation was followed by Glut-4 translocation to the plasma membrane and increase of glucose uptake. Then, IRS-1 was phosphorylated at S612, the IRS-1/p85PI3K complex was disrupted, Akt was no more phosphorylated and both Glut-4 translocation and glucose uptake were reduced. Inhibition of CaMKII abrogated the insulin-induced Erk-1/2 activation, DNA synthesis and phosphorylation of IRS-1 at S612. Inhibition of CaMKII also abrogated the down-regulation of insulin-stimulated Akt phosphorylation, Glut-4 membrane translocation and glucose uptake.
These results demonstrate that: 1 - CaMKII modulates the insulin-induced Erk-1/2 activation and cell proliferation; 2 - after the initial stimulation of the IRS-1/Akt pathway, CaMKII mediates the down-regulation of stimulated glucose uptake. This represents a novel mechanism in the selective control of insulin signals, and a possible site for pharmacological intervention. (literal)
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