http://www.cnr.it/ontology/cnr/individuo/prodotto/ID14058

In vivo properties of the proangiogenic peptide QK. (Articolo in rivista)

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In vivo properties of the proangiogenic peptide QK. (Articolo in rivista) (literal)

Anno

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Alternative label

Santulli Gaetano; Ciccarelli Michele; Palumbo Gianluigi; Campanile Alfonso; Galasso Gennaro; Ziaco Barbara; Altobelli Giovanna Giuseppina; Cimini Vincenzo; Piscione Federico; D'Andrea Luca Domenico; Pedone Carlo; Trimarco Bruno; Iaccarino Guido (2009)
In vivo properties of the proangiogenic peptide QK.
in Journal of translational medicine (Online)
(literal)

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Santulli Gaetano; Ciccarelli Michele; Palumbo Gianluigi; Campanile Alfonso; Galasso Gennaro; Ziaco Barbara; Altobelli Giovanna Giuseppina; Cimini Vincenzo; Piscione Federico; D'Andrea Luca Domenico; Pedone Carlo; Trimarco Bruno; Iaccarino Guido (literal)

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Santulli Gaetano; Univ Naples Federico 2, Cattedra Med Interna, Dipartimento Med Clin Sci Cardiovasc & Immunol, Naples, Italy Ciccarelli Michele; Univ Naples Federico 2, Cattedra Med Interna, Dipartimento Med Clin Sci Cardiovasc & Immunol, Naples, Italy Palumbo Gianluigi; Univ Naples Federico 2, Cattedra Med Interna, Dipartimento Med Clin Sci Cardiovasc & Immunol, Naples, Italy Campanile Alfonso; Univ Naples Federico 2, Cattedra Med Interna, Dipartimento Med Clin Sci Cardiovasc & Immunol, Naples, Italy Galasso Gennaro; Univ Naples Federico 2, Cattedra Cardiol, Dipartimento Med Clin Sci Cardiovasc & Immunol, Naples, Italy Ziaco Barbara; CNR, Ist Biostrutture & Bioimmagini, I-80125 Naples, Italy Altobelli Giovanna Giuseppina; Univ Naples Federico 2, Dipartimento Sci Biomorfol & Funzionali, Naples, Italy Cimini Vincenzo; Univ Naples Federico 2, Dipartimento Sci Biomorfol & Funzionali, Naples, Italy Piscione Federico; Univ Naples Federico 2, Cattedra Cardiol, Dipartimento Med Clin Sci Cardiovasc & Immunol, Naples, Italy D'Andrea Luca Domenico; CNR, Ist Biostrutture & Bioimmagini, I-80125 Naples, Italy Pedone Carlo; Univ Naples Federico 2, Dipartimento Sci Biol, Naples, Italy Trimarco Bruno; Univ Naples Federico 2, Cattedra Med Interna, Dipartimento Med Clin Sci Cardiovasc & Immunol, Naples, Italy Iaccarino Guido; Univ Naples Federico 2, Cattedra Med Interna, Dipartimento Med Clin Sci Cardiovasc & Immunol, Naples, Italy (literal)

Titolo

Abstract

The main regulator of neovascularization is Vascular Endothelial Growth Factor (VEGF). We recently demonstrated that QK, a de novo engineered VEGF mimicking peptide, shares in vitro the same biological properties of VEGF, inducing capillary formation and organization. On these grounds, the aim of this study is to evaluate in vivo the effects of this small peptide. Therefore, on Wistar Kyoto rats, we evaluated vasomotor responses to VEGF and QK in common carotid rings. Also, we assessed the effects of QK in three different models of angiogenesis: ischemic hindlimb, wound healing and Matrigel plugs. QK and VEGF present similar endothelium-dependent vasodilatation. Moreover, the ability of QK to induce neovascularization was confirmed us by digital angiographies, dyed beads dilution and histological analysis in the ischemic hindlimb as well as by histology in wounds and Matrigel plugs. Our findings show the proangiogenic properties of QK, suggesting that also in vivo this peptide resembles the full VEGF protein. These data open to new fields of investigation on the mechanisms of activation of VEGF receptors, offering clinical implications for treatment of pathophysiological conditions such as chronic ischemia. (literal)

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