http://www.cnr.it/ontology/cnr/individuo/prodotto/ID14056
Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution (Articolo in rivista)
- Type
- Label
- Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1111/j.1365-2362.2010.02372.x (literal)
- Alternative label
Bozzetto L; Prinster, A; Mancini, M; Giacco, R; De Natale, C; Salvatore, M; Riccardi, G; Rivellese, AA; Annuzzi, G (2010)
Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution
in European journal of clinical investigation (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Bozzetto L; Prinster, A; Mancini, M; Giacco, R; De Natale, C; Salvatore, M; Riccardi, G; Rivellese, AA; Annuzzi, G (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- *Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy, +Institute of Biostructure and
Bioimage, National Research Council, Naples, Italy, ?SDN Foundation, Institute of Diagnostic and Nuclear Development,
Naples, Italy, §Institute of Food Sciences, National Research Council, Avellino, Italy, ¶Department of Biomorphological and
Functional Science, Federico II University, Naples, Italy (literal)
- Titolo
- Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution (literal)
- Abstract
- Background Fatty liver is commonly associated with insulin-resistant conditions, often related to increased
abdominal visceral fat. Our objective was to elucidate the specific roles of obesity, type 2 diabetes mellitus,
insulin-resistance and abdominal fat distribution.
Materials and methods The study population comprised 13 diabetic obese (DO), 10 nondiabetic obese (NDO),
and nine normal-weight control (C) men aged 28-65 years, with normal plasma triglyceride levels. DO were in
good glycaemic control (HbA1c = 6Æ8 ± 0Æ8%) (M ± SD) with diet (n = 8) or diet + metformin (n = 5). Liver fat
content was measured by 1H-magnetic resonance spectroscopy, abdominal fat distribution by magnetic
resonance imaging and insulin sensitivity by hyperinsulinaemic euglycaemic clamp.
Results DO and NDO subjects had similar whole-body insulin resistance, BMI and waist circumference, higher
than those of C subjects (P < 0Æ001). DO had more liver fat (11Æ9 ± 7Æ0%) than NDO (5Æ2 ± 2Æ8%, P < 0Æ05) and
C (1Æ6 ± 1Æ0%, P < 0Æ001). Abdominal fat was greater in DO and NDO than in C (visceral: DO 3184 ± 843, NDO
2843 ± 1378 vs. C 1212 ± 587 cm3, P < 0Æ001; subcutaneous: DO 4029 ± 362, NDO 5197 ± 1398 vs. C
2312 ± 626 cm3, P < 0Æ001), visceral fat being not significantly different between the two obese groups, and
subcutaneous fat significantly less in DO than in NDO (P < 0Æ05).
Conclusions Type 2 diabetes is associated with increased fat accumulation in the liver, independent of obesity
and whole-body insulin resistance. The increased liver fat in DO patients may be part of an altered regional fat
distribution that includes an inadequate subcutaneous fat storing capacity, rather than simply being a consequence
of increased abdominal visceral content. (literal)
- Prodotto di
- Autore CNR
- Insieme di parole chiave
Incoming links:
- Autore CNR di
- Prodotto
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
- Insieme di parole chiave di