Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1159/000276765 (literal)

Alternative label

• Insabato, L; Amelio, I; Quarto, M; Zannetti, A; Tolino, F; de Mauro, G; Cerchia, L; Riccio, P; Baumhoer, D; Condorelli, G; Terracciano, L; de Franciscis, V (2010)
  Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors
  in Oncology (Basel)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Insabato, L; Amelio, I; Quarto, M; Zannetti, A; Tolino, F; de Mauro, G; Cerchia, L; Riccio, P; Baumhoer, D; Condorelli, G; Terracciano, L; de Franciscis, V (literal)

Pagina inizio

• 378 (literal)

Pagina fine

• 384 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 77 (literal)

Rivista

• Oncology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Biomorphological and Functional Science, Anatomic Pathology Section, Faculty of Medicine, Università degli Studi di Napoli Federico II, Napoli, Italia Istituto di Biostrutture e Bioimmagini, CNR - IBB, Napoli, Italy (literal)

Titolo

• Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors (literal)

Abstract

• OBJECTIVES: Protein tyrosine phosphatases are key regulators of intracellular signaling that contribute to determining cancer cell growth, which thus makes them attractive targets for therapeutic and diagnostic agents. SHP-1 phosphotyrosine phosphatase is rarely expressed in epithelial tumor cells, but expression has been found in several breast cancer cell lines and tumors. To determine the potential significance of SHP-1 as a prognostic marker in the clinical setting, we examined SHP-1 protein expression in breast tumors. METHODS: We analyzed SHP-1 expression by immunohistochemistry in a breast tissue microarray composed of 2,081 cores, either alone or in combination with known prognostic markers. RESULTS: Our data showed that SHP-1 expression was confined to a well-defined subset of high-grade tumors characterized by unique biological parameters. SHP-1 expression correlated directly with expression of the tyrosine kinase receptor HER-2 and inversely with expression of the estrogen receptor, while it was weakly associated with Bcl-2 expression. CONCLUSIONS: Levels of SHP-1 were correlated with conventional pathologic parameters of tumor aggressiveness and were associated with reduced patient survival, suggesting that elevated expression of SHP-1 is a common molecular abnormality in a defined subset of breast tumors and might be used in routine diagnosis to identify patients with high-risk tumors (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Imaging Molecolare in Oncologia, Sintesi di Molecole Radiomarcate e Sviluppo di Approcci Diagnostici e Terapeutici Innovativi (ME.P03.001.001) (Modulo)

Autore CNR

• VITTORIO DE FRANCISCIS (Persona)
• ANTONELLA ZANNETTI (Unità di personale interno)

Incoming links:

Autore CNR di

• VITTORIO DE FRANCISCIS (Persona)
• ANTONELLA ZANNETTI (Unità di personale interno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Imaging Molecolare in Oncologia, Sintesi di Molecole Radiomarcate e Sviluppo di Approcci Diagnostici e Terapeutici Innovativi (ME.P03.001.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Oncology (Rivista)