Diffusion-Weighted Imaging in Multiple System Atrophy: A Comparison Between Clinical Subtypes (Articolo in rivista)

Type
Label
  • Diffusion-Weighted Imaging in Multiple System Atrophy: A Comparison Between Clinical Subtypes (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/mds.22440 (literal)
Alternative label
  • Pellecchia, MT; Barone, P; Mollica, C; Salvatore, E; Ianniciello, M; Longo, K; Varrone, A; Vicidomini, C; Picillo, M; De Michele, G; Filla, A; Salvatore, M; Pappata, S (2009)
    Diffusion-Weighted Imaging in Multiple System Atrophy: A Comparison Between Clinical Subtypes
    in Movement disorders; WILEY-LISS, DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pellecchia, MT; Barone, P; Mollica, C; Salvatore, E; Ianniciello, M; Longo, K; Varrone, A; Vicidomini, C; Picillo, M; De Michele, G; Filla, A; Salvatore, M; Pappata, S (literal)
Pagina inizio
  • 689 (literal)
Pagina fine
  • 696 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 24 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Neurological Sciences, University Federico II, Naples, Italy Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II, Naples, Italy IRCCS Fondazione SDN, Naples, Italy (literal)
Titolo
  • Diffusion-Weighted Imaging in Multiple System Atrophy: A Comparison Between Clinical Subtypes (literal)
Abstract
  • Multiple system atrophy call be classified into two main types, a Parkinsonian (MSA-P) and a cerebellar (MSA-C) variant based on clinical presentation. We obtained diffusion-weighted magnetic resonance imaging (DWI) in 9 MSA-P and 12 MSA-C patients and 11 controls, and correlated DWI changes with disease duration and severity. We found that Trace (D) values in the entire and anterior putamen were significantly higher in MSA-P than in MSA-C patients and controls, whereas Trace (D) values in the cerebellum and middle cerebellar peduncle (MCP) were significantly higher in MSA-C than in MSA-P patients and controls. Increased disease duration was significantly correlated with increased Trace (D) values in pons of MSA-P patients, and in cerebellum and MCP of MSA-C patients. Both UMSARS and UPDRS motor scores positively correlated with entire and posterior putaminal Trace (D) values in MSA-P patients. The diffusivity changes parallel phenotypical and pathologic differences between MSA-P and MSA-C patients, suggesting that DWI is a feasible tool for in vivo evaluation of neurodegeneration in MSA. Based on our findings, Trace (D) measurements in the putamen and pons in MSA-P patients and in the cerebellum and MCP in MSA-C patients could serve as quantitative markers for microstructural damage in the course of disease. (literal)
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