http://www.cnr.it/ontology/cnr/individuo/prodotto/ID13986
Diffusion-Weighted Imaging in Multiple System Atrophy: A Comparison Between Clinical Subtypes (Articolo in rivista)
- Type
- Label
- Diffusion-Weighted Imaging in Multiple System Atrophy: A Comparison Between Clinical Subtypes (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/mds.22440 (literal)
- Alternative label
Pellecchia, MT; Barone, P; Mollica, C; Salvatore, E; Ianniciello, M; Longo, K; Varrone, A; Vicidomini, C; Picillo, M; De Michele, G; Filla, A; Salvatore, M; Pappata, S (2009)
Diffusion-Weighted Imaging in Multiple System Atrophy: A Comparison Between Clinical Subtypes
in Movement disorders; WILEY-LISS, DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 (Stati Uniti d'America)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Pellecchia, MT; Barone, P; Mollica, C; Salvatore, E; Ianniciello, M; Longo, K; Varrone, A; Vicidomini, C; Picillo, M; De Michele, G; Filla, A; Salvatore, M; Pappata, S (literal)
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- Department of Neurological Sciences, University Federico II, Naples, Italy
Institute of Biostructure and Bioimaging, CNR,
Department of Biomorphological Sciences, University Federico II, Naples, Italy
IRCCS Fondazione SDN, Naples, Italy (literal)
- Titolo
- Diffusion-Weighted Imaging in Multiple System Atrophy: A Comparison Between Clinical Subtypes (literal)
- Abstract
- Multiple system atrophy call be classified into two main types, a Parkinsonian (MSA-P) and a cerebellar (MSA-C) variant based on clinical presentation. We obtained diffusion-weighted magnetic resonance imaging (DWI) in 9 MSA-P and 12 MSA-C patients and 11 controls, and correlated DWI changes with disease duration and severity. We found that Trace (D) values in the entire and anterior putamen were significantly higher in MSA-P than in MSA-C patients and controls, whereas Trace (D) values in the cerebellum and middle cerebellar peduncle (MCP) were significantly higher in MSA-C than in MSA-P patients and controls. Increased disease duration was significantly correlated with increased Trace (D) values in pons of MSA-P patients, and in cerebellum and MCP of MSA-C patients. Both UMSARS and UPDRS motor scores positively correlated with entire and posterior putaminal Trace (D) values in MSA-P patients. The diffusivity changes parallel phenotypical and pathologic differences between MSA-P and MSA-C patients, suggesting that DWI is a feasible tool for in vivo evaluation of neurodegeneration in MSA. Based on our findings, Trace (D) measurements in the putamen and pons in MSA-P patients and in the cerebellum and MCP in MSA-C patients could serve as quantitative markers for microstructural damage in the course of disease. (literal)
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