Sonographic hepatic-renal ratio as indicator of hepatic steatosis: comparison with H-1 magnetic resonance spectroscopy (Articolo in rivista)

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  • Sonographic hepatic-renal ratio as indicator of hepatic steatosis: comparison with H-1 magnetic resonance spectroscopy (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.metabol.2009.05.032 (literal)
Alternative label
  • Mancini, M; Prinster, A; Annuzzi, G; Liuzzi, R; Giacco, R; Medagli, C; Cremone, M; Clemente, G; Maurea, S; Riccardi, G; Rivellese, AA; Salvatore, M (2009)
    Sonographic hepatic-renal ratio as indicator of hepatic steatosis: comparison with H-1 magnetic resonance spectroscopy
    in Metabolism, clinical and experimental (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mancini, M; Prinster, A; Annuzzi, G; Liuzzi, R; Giacco, R; Medagli, C; Cremone, M; Clemente, G; Maurea, S; Riccardi, G; Rivellese, AA; Salvatore, M (literal)
Pagina inizio
  • 1724 (literal)
Pagina fine
  • 1730 (literal)
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  • 58 (literal)
Rivista
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  • 7 (literal)
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  • 12 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR, Biostruct & Bioimaging Inst, I-80125 Naples, Italy SDN Fdn, Inst Diagnost & Nucl Dev Naples, Naples, Italy Univ Naples Federico 2, Dept Clin & Expt Med, Naples, Italy CNR, Inst Food Sci, Avellino, Italy Univ Naples Federico 2, Dept Biomorphol & Funct Sci, Naples, Italy (literal)
Titolo
  • Sonographic hepatic-renal ratio as indicator of hepatic steatosis: comparison with H-1 magnetic resonance spectroscopy (literal)
Abstract
  • The aim of this study was to determine the diagnostic performance of ultrasound (US) in the quantitative assessment of steatosis by comparison with proton magnetic resonance spectroscopy ((1)H-MRS) as a reference standard. Three liver echo-intensity indices were derived: US hepatic mean gray level, hepatic-renal echo-intensity ratio (H/R), and hepatic-portal blood echo-intensity ratio. The (1)H-MRS degree of steatosis was determined as percentage fat by wet weight. Regression equations were used to estimate quantitatively hepatic fat content. The hepatic fat content by (1)H-MRS analysis ranged from 0.10% to 28.9% (median value, 4.8%). Ultrasound H/R was correlated with the degree of steatosis on (1)H-MRS (R(2) = 0.92; P < .0001), whereas no correlation with (1)H-MRS was found for hepatic mean gray level and hepatic-portal blood echo-intensity ratio. A receiver operating characteristic curve identified the H/R of 2.2 as the best cutoff point for the prediction of (1)H-MRS of at least 5%, yielding measures of sensitivity and specificity of 100% and 95%, respectively. In this pilot study, US H/R exhibits high sensitivity and specificity for detecting liver fatty changes. Our results indicate that quantitative evaluation of hepatic fat content can be performed using US H/R and could therefore be a valuable analytic tool in clinical investigation. (literal)
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