Molecular imaging of drug resistance in cancer (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Molecular imaging of drug resistance in cancer (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Alternative label

• Del Vecchio, S; Zannetti, A; Fonti, R; Iommelli, F; Lettieri, A; Salvatore, M (2009)
  Molecular imaging of drug resistance in cancer
  in Minerva biotecnologica (Testo stamp.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Del Vecchio, S; Zannetti, A; Fonti, R; Iommelli, F; Lettieri, A; Salvatore, M (literal)

Pagina inizio

• 31 (literal)

Pagina fine

• 36 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 21 (literal)

Rivista

• Minerva biotecnologica (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Biomorphological and Functional Sciences University \"Federico II\", Naples, Italy Institute of Biostructures and Bioimages of the National Research Council (CNR), Naples, Italy (literal)

Titolo

• Molecular imaging of drug resistance in cancer (literal)

Abstract

• Multidrug resistance remains the primary cause of treatment failure in cancer patients. Among the multiple cellular mechanisms underlying the resistant phenotype, the enhanced efflux of anticancer drugs mediated by members of the ATP-binding cassette family of transporters such as P-glycoprotein (Pgp) and the reduced apoptosis due to dysregulation of the process are the most common causes of drug resistance. Here we report the results of our studies on the possibility to detect in vivo and non-invasively malignant tumors that will become resistant to subsequent therapy using single-photon emission tomography and 99mTc-Sestamibi, a tumor-seeking agent currently used in clinical practice. This tracer is a lipophilic cation that accumulates in mitochondria in response to plasma membrane e mitochondrial membrane potentials. In addition, the tracer is subjected to Pgp-mediated outward transport thus mimicking the kinetic behaviour of anticancer drugs in resistant cells. Our studies showed that both the uptake and efflux mechanisms of 99mTc-Sestamibi can be helpful for the non-invasive assessment of drug resistance in cancer. While an enhanced tracer clearance is an index of Pgp-function, an altered pattern of tracer uptake is associated with an impaired apoptosis due to Bcl-2/Bcl-xL overexpression or unopposed action. In conclusion, molecular imaging of drug resistance is suitable and may provide biological information that can improve the efficacy of individual-tailored therapeutic strategies. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Imaging Molecolare in Oncologia, Sintesi di Molecole Radiomarcate e Sviluppo di Approcci Diagnostici e Terapeutici Innovativi (ME.P03.001.001) (Modulo)

Autore CNR

• FRANCESCA IOMMELLI (Unità di personale interno)
• SILVANA DEL VECCHIO (Persona)
• ROSA FONTI (Unità di personale interno)
• ANTONELLA ZANNETTI (Unità di personale interno)
• MARCO SALVATORE (Persona)

Incoming links:

Autore CNR di

• SILVANA DEL VECCHIO (Persona)
• MARCO SALVATORE (Persona)
• ROSA FONTI (Unità di personale interno)
• ANTONELLA ZANNETTI (Unità di personale interno)
• FRANCESCA IOMMELLI (Unità di personale interno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Imaging Molecolare in Oncologia, Sintesi di Molecole Radiomarcate e Sviluppo di Approcci Diagnostici e Terapeutici Innovativi (ME.P03.001.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Minerva biotecnologica (Rivista)