New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.ejmech.2007.03.038 (literal)

Alternative label

• Bellia F.; A.M. Amorini; D. La Mendola; G. Vecchio; B. Tavazzi; B. Giardina; V. Di Pietro; G. Lazzarino; E. Rizzarelli (2008)
  New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity
  in European journal of medicinal chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bellia F.; A.M. Amorini; D. La Mendola; G. Vecchio; B. Tavazzi; B. Giardina; V. Di Pietro; G. Lazzarino; E. Rizzarelli (literal)

Pagina inizio

• 373 (literal)

Pagina fine

• 380 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 43 (literal)

Rivista

• European journal of medicinal chemistry (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• F. Bellia, Department of Chemical Sciences, University of Catania, Italy A.M. Amorini, Department of Chemical Sciences, University of Catania, Italy G. Vecchio, Department of Chemical Sciences, University of Catania, Italy G. Lazzarino, Department of Chemical Sciences, University of Catania, Italy E. Rizzarelli, Department of Chemical Sciences, University of Catania, Italy B. Tavazzi, Institute of Biochemistry and Clinical Biochemistry, Catholic University of Rome, Italy B. Girdina, Institute of Biochemistry and Clinical Biochemistry, Catholic University of Rome, Italy V. Di Pietro, Institute of Biochemistry and Clinical Biochemistry, Catholic University of Rome, Italy (literal)

Titolo

• New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (literal)

Abstract

• Synthesis, antioxidant properties and resistance to camosinase hydrolysis of histidine-containing dipeptides are reported in this study. Carnosine (beta-alanyl-L-histidine), homocamosine (gamma-aminobutyryl-L-histidine) and anserine (beta-alanyl-3-methyl-L-histidine) were covalently derivatized with beta-cyclodextrin to form different OH- or NH-bound conjugates. Mass spectroscopic and (1)H NMR data were used to determine the structure and the purity of the various beta-cyclodextrin derivatives. The inhibitory effect towards oxidation of human LDL induced by Cu(2+) ions, was estimated by measuring malondialdehyde formation as a function of increasing concentrations of these newly synthesized compounds (the beta-cyclodextrin-anserine conjugated in 3 had the highest antioxidant effect). All derivatives had higher antioxidant effects than those of the corresponding free histidine-containing dipeptides. Resistance to rat brain camosinase hydrolysis of the most active derivatives indicated that these compounds are good candidates for further studies in more complex cellular and animal models. Their possible applications for remedies in neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, are discussed. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Progettazione e sintesi di nuovi composti bioattivi e loro veicolazione sito specifica. (PM.P01.003.002) (Modulo)

Autore CNR

• ENRICO RIZZARELLI (Unità di personale esterno)
• FRANCESCO BELLIA (Unità di personale interno)
• DIEGO LA MENDOLA (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• DIEGO LA MENDOLA (Unità di personale interno)
• ENRICO RIZZARELLI (Unità di personale esterno)
• FRANCESCO BELLIA (Unità di personale interno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Progettazione e sintesi di nuovi composti bioattivi e loro veicolazione sito specifica. (PM.P01.003.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European journal of medicinal chemistry (Rivista)

Insieme di parole chiave di

• Parole chiave di "New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity" (Insieme di parole chiave)