Regulatory T-cells in the celiac intestinal mucosa: a new perspective for treatment? (Monografia o trattato scientifico)

Type

• Prodotto della ricerca (Classe)
• Monografia o trattato scientifico (Classe)

Label

• Regulatory T-cells in the celiac intestinal mucosa: a new perspective for treatment? (Monografia o trattato scientifico) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Gianfrani C, Camarca A, Salvati V, Mazzarella G, Roncarolo MG and Troncone R. (2008)
  Regulatory T-cells in the celiac intestinal mucosa: a new perspective for treatment?
  Karger, Basel (Swaziland), 2008
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Gianfrani C, Camarca A, Salvati V, Mazzarella G, Roncarolo MG and Troncone R. (literal)

Pagina inizio

• 181 (literal)

Pagina fine

• 187 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#citta

• Branski (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#volumeInCollana

• Vol 12 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Vol 12:181-187 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#curatori

• Editori: A. Fasano, D. Branski, R. Troncone (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Food Sciences, CNR Avellino, Avellino, Department of Paediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University Federico II, Naples San Raffaele Telethon Institute of Gene Therapy, San Raffaele Scientific Institute Milan, Milan, Italy (literal)

Titolo

• Regulatory T-cells in the celiac intestinal mucosa: a new perspective for treatment? (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#isbn

• 978-3-8055-8526-2 (literal)

Abstract

• In the physiological condition, the immune system tolerizes the huge amount of proteins that are daily introduced into the gastro-intestinal tract with the diet, a phenomenon known as oral tolerance. Many and complex immunological mechanisms are involved in the induction of oral tolerance including suppression by regulatory T cells (Treg). In addition, a key role in the gut homoeostasis is sustained by immunosuppressive cytokines, such as interleukin (IL)-10 and transforming growth factor (TGF) , released by Treg. Coeliac disease is a common, and almost worldwide spread, intolerance to wheat gluten and related proteins from barley and rye. Coeliac disease is caused by abnormal pro-inflammatory responses to ingested gluten in which gliadin-reactive T cells are one of the main actors in orchestrating the complex adverse immune reactions following gluten ingestion. Our recent studies have revealed that the treatment with IL-10 of small-intestinal mucosa from coeliac disease patients in remission prevents the massive immune activation induced by gluten challenge. Furthermore, we have observed that coeliac intestinal mucosa harbours a subset of Treg, the Tr1, that through the release of both IL-10 and TGF- inhibit the pathogenic response to in vitro gluten challenge. Herein we discuss these recent studies on Treg in coeliac disease mucosa and envision an IL-10-based therapeutic approach for coeliac disease. (literal)

Editore

• Karger (Editore)

Prodotto di

• Bioassay cellulari per l’analisi della proprietà immunostimolanti degli alimenti (AG.P05.005.008) (Modulo)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)
• Institute of food sciences (ISA) (Istituto)

Autore CNR

• CARMELA GIANFRANI (Unità di personale interno)
• GIUSEPPE MAZZARELLA (Unità di personale interno)

Incoming links:

Prodotto

• Institute of food sciences (ISA) (Istituto)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)
• Bioassay cellulari per l’analisi della proprietà immunostimolanti degli alimenti (AG.P05.005.008) (Modulo)

Autore CNR di

• GIUSEPPE MAZZARELLA (Unità di personale interno)
• CARMELA GIANFRANI (Unità di personale interno)

Editore di

• Karger (Editore)